Etiology of Breast and Gynecological Cancers

C.Marcelo Aldaz, etc., Michael Gould, John McLachlan, Thomas Slaga (Herausgeber)

Buch | Hardcover

296 Seiten

1997
John Wiley & Sons Inc (Verlag)
978-0-471-16901-7 (ISBN)

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Despite recent advances in research and prevention, the incidence of common female cancers is still increasing. This book reviews the most recent advances in the fields of breast and gynecological carcinogenesis. It discusses the validity of animal models for study of these human diseases and addresses the relative contributions of genetic predisposition and environmental exposure to potential carcinogens including environmental hormone disrupters.

Toward a unified concept of mammary carcinogenesis; epidemiologic analysis of breast and gynaecologic cancers; recent advances in the molecular genetics of hereditary breast and ovarian cancer; defining etiologic heterogeneity in breast cancer using genetic biomarkers; the genetics of sporadic breast cancer; molecular epidemiology of breast cancer; molecular perspectives on cancer, the cell cycle and the inherited disorder ataxia-telangiectasi; radiation and breast cancer risk; genotoxicity of environmental agents in human mammary epithelial cells - a trigger for human breast cancer; organochlorine exposure and risk for breast cancer; diet and breast cancer - opportunities for prevention and intervention; perspectives and progress in development of breast cancer chemopreventive drugs; the molecular genetics of endometrial carcinoma; rodent model of reproductive tract leiomyomata - characterization and use in preclinical therapeutic studies; mechanisms of DES carcinogenicity - effects of the TGF (transgene); estrogens and the genetic control of tumour growth; targeted antiestrogens; the metabolism and genotoxicity of tamoxifen; tamoxifen breast cancer prevention trial - an update.

Erscheint lt. Verlag	27.3.1997
Reihe/Serie	Progress in Clinical & Biological Research
Zusatzinfo	illustrations, photographs
Verlagsort	New York
Sprache	englisch
Maße	159 x 236 mm
Gewicht	603 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Gynäkologie / Geburtshilfe
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Studium ► Querschnittsbereiche ► Epidemiologie / Med. Biometrie
ISBN-10	0-471-16901-3 / 0471169013
ISBN-13	978-0-471-16901-7 / 9780471169017
Zustand	Neuware