Recurrent Implantation Failure

Etiologies and Clinical Management

Jason M. Franasiak, Richard T. Scott Jr. (Herausgeber)

Buch | Hardcover

XIII, 215 Seiten

2018 | 1st ed. 2018
Springer International Publishing (Verlag)
978-3-319-71966-5 (ISBN)

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This unique text discusses the wide range of causes and pathophysiologic conditions contributing to recurrent implantation failure (RIF) and the current treatment approaches to best approach this challenging patient population. Beginning with a presentation of the mechanism of normal implantation, the physiologic synchrony between embryo and endometrium, and the roles of both gametes and embryos in RIF, the book then examines the various genetic, immune and environmental factors involved. Abnormalities of the hematologic and endocrine system, as well as those of the anatomy and microbiome, are described in detail. Last but no less important, the psychological stress and treatment of patients experiencing RIF is discussed.

Assisted reproductive technology (ART) success has increased substantially over the past three decades. However, despite these advances, recurrent implantation failure is still a common issue confronting patients and clinicians, and RIF represents one of the greatest challenges in ART and remains a source of frustration and disappointment for patients, clinicians, and researchers involved in the process. Providing an in-depth investigation into the pathophysiology and biological mechanisms of RIF and its clinical management, this will be an excellent resource for reproductive endocrinologists and infertility specialists.

Jason M. Franasiak, MD, TS (ABB), Assistant Professor, Sidney Kimmel Medical School, Thomas Jefferson University, Reproductive Medicine Associates of New Jersey, Basking Ridge, NJ, USA Richard T. Scott, MD, HCLD/ALD (ABB), Professor, Sidney Kimmel Medical School, Thomas Jefferson University, Reproductive Medicine Associates of New Jersey, Basking Ridge, NJ, USA

Signaling Between Embryo and Endometrium: Normal Implantation.- Embryo and Endometrial Synchrony in Implantation Failure.- Spermatogenesis: Fertile Ground for Contributing to Recurrent Implantation Failure?- Embryonic Factors Associated with Recurrent Implantation Failure.- The Genetics of Pregnancy Failure.- Immune Factors in Recurrent Implantation Failure.- Stress and Recurrent Implantation Failure.- Hematologic Disease in Recurrent Implantation Failure.- Endocrine Causes of Recurrent Implantation Failure.- Anatomic Abnormalities and Recurrent Implantation Failure.- Microbiome in Embryonic Implantation and Recurrent Implantation Failure.- Psychosocial Implications of Recurrent Implantation Failure.

Erscheinungsdatum	21.04.2018
Zusatzinfo	XIII, 215 p. 32 illus., 29 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Gewicht	450 g
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Endokrinologie
Themenwelt	Studium ► 1. Studienabschnitt (Vorklinik) ► Histologie / Embryologie
Schlagworte	Anatomic abnormality • ART • Assisted hatching • Assisted Reproductive Technology • Blastocyst transfer • Embryo • Endometrial synchrony • environmental factor • Gamete • Immune factors • microbiome • Oocyte • pregnancy loss • Preimplantation genetic diagnosis • Recurrent implant failure • Rif • Sperm
ISBN-10	3-319-71966-1 / 3319719661
ISBN-13	978-3-319-71966-5 / 9783319719665
Zustand	Neuware