Eicosanoids and the Skin

Thomas Ruzicka (Autor)

Buch | Hardcover

224 Seiten

1990
Crc Press Inc (Verlag)
978-0-8493-6032-9 (ISBN)

Titel ist leider vergriffen;
keine Neuauflage

Artikel merken

This publication summarizes the increasing knowledge in eicosanoid research. It provides a detailed overview of this rapidly expanding field. The text contains sections on general aspects of arachidonic acid metabolism, the role of eicosanoids in skin diseases, and their biological and biochemical effects in skin. Also included is a section on inhibitors of arachidonic acid metabolism with particular reference to use in dermatology. New concepts covered are: possible physiological role of lipoxygenase products in cutaneous wound healing, restoration and maintenance of cutaneous integrity, and the recently recognized protective function of prostaglandins in skin. It is an invaluable resource for individuals involved with dermatology, pharmacology, inflammation, immunology, biochemistry, physiology, internal medicine and therapeutics.

Part I. ARACHIDONIC ACID METABOLISM - GENERAL ASPECTS. Arachidonic Acid Metabolism - Enzymatic Pathways. Arachidonic Acid Metabolism in Normal Skin. Receptors for Lipoxygenase-Derived Eicosanoids on Epidermal Cells. Leukotriene B4 Catabolism by Rodent and Human Skin. Part II. ROLE OF ARACHIDONIC ACID METABOLISM IN SKIN DISEASES. Eicosanoids in Inflammatory Skin Diseases. Eicosanoids, Phosphoinositides and the Pathophysiology of Psoriasis. Identification of 5-HETE-Specific Chemotaxis Inhibitor in Scales of Patients with Psoriasis. Arachidonic Acid Metabolism in Ultraviolet Light Dermatitis. Role of Eicosanoids in Normal, Hyperplastic, and Neoplastic Growth in Mouse Skin. Part III. BIOLOGICAL AND BIOCHEMICAL EFFECT OF ARACHIDONIC ACID METABOLITES IN SKIN. Effects of Arachidonic Acid Metabolites on Leukocyte Function. Effects of Eicosanoids on Human Fibroblast Chemotaxis. Effects of Eicosanoids on Microcirculation in the Skin. Part IV. INHIBITORS OF CUTANEOUS ARACHIDONIC ACID METABOLISM. Glucocorticosteroids and Nonsteroidal Anti-inflammatory Drug-Mechanism of Action and Their Role in the Treatment of Skin Diseases. Inhibitors of Arachidonic Acid Cascade and Their Potential Use in Prevention of Skin Carcinogenesis. Part V. EICOSANOIDS AND THE SKIN - NEW CONCEPTS. Eicosanoids and the Skin - New Concepts Evolving. Index,

Erscheint lt. Verlag	30.3.1990
Zusatzinfo	18 Tables, black and white
Verlagsort	Bosa Roca
Sprache	englisch
Maße	178 x 254 mm
Gewicht	635 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Dermatologie
ISBN-10	0-8493-6032-3 / 0849360323
ISBN-13	978-0-8493-6032-9 / 9780849360329
Zustand	Neuware