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Interaction of Mycophenolic Acid and Pantoprazole

A Pharmacokinetic Crossover Study

Olesja Rissling (Autor)

Buch | Softcover

XXII, 162 Seiten

2017 | 1st ed. 2017
Springer Fachmedien Wiesbaden GmbH (Verlag)
978-3-658-19888-6 (ISBN)

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Olesja Rissling analyzes the potential interaction of mycophenolic acid (MPA) and pantoprazole. MPA is used as an immunosuppressive drug to prevent acute organ rejections after organ transplantation. Pantoprazole, known to interact with the bioavailability of drugs, is used to prevent upper gastrointestinal disorders. The author performed a clinical pharmacokinetic study in renal transplant patients to evaluate a potential interaction of MPA and pantoprazole. The bioavailability and the maximum concentration of MPA were determined with or without pantoprazole intake. An influence on the immunosuppressive effect was evaluated by measuring the target enzyme activity. Overall, no significant change in the bioavailability or the maximum concentration was found. Similar results were obtained for the target enzyme activity after pantoprazole intake with MPA. The results suggest that the interaction of pantoprazole with MPA does not compromise the immunosuppressive effect to a clinically meaningful extent.

Olesja Rissling studied pharmacy and works as a research associate at the Federal Joint Committee in the field of benefit assessment of pharmaceuticals.

Validation of an Assay for Quantification of MPA and MPAG.- Clinical Study of a PK Interaction of Pantoprazole and MPA.- Bioequivalence Analysis.

Erscheinungsdatum	03.12.2017
Zusatzinfo	XXII, 162 p. 23 illus., 10 illus. in color.
Verlagsort	Wiesbaden
Sprache	englisch
Maße	148 x 210 mm
Gewicht	246 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Laboratoriumsmedizin
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pharmazie
Schlagworte	clinical transplantation • Drug-Drug-Interactions • Enzyme activity • Gastrointestinal disorders • Immunosuppressives • renal transplantation
ISBN-10	3-658-19888-5 / 3658198885
ISBN-13	978-3-658-19888-6 / 9783658198886
Zustand	Neuware