Mechanistic Toxicology

The Molecular Basis of How Chemicals Disrupt Biological Targets, Second Edition

Urs A. Boelsterli (Autor)

Buch | Hardcover

416 Seiten

2017 | 2nd edition
CRC Press (Verlag)
978-1-138-47362-1 (ISBN)

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A thorough understanding of cellular and molecular mechanisms involved in the individual expression of toxic effects provides an important tool for assessment of human health risk. New aspects, major advances, and new areas in molecular and cellular biology and toxicology demand updated sources of information to elucidate the functional mechanics of human toxicology.

Mechanistic Toxicology: The Molecular Basis of How Chemicals Disrupt Biological Targets, Second Edition retains the accessible format of the original to present the general principles that link xenobiotic-induced toxicity with the molecular pathways that underlie these toxic effects. Extensively illustrated, this book forms a conceptual bridge between multiple events at the molecular level and the determinants of toxicity at the physiological and cellular level. Specific examples of drugs, environmental pollutants, and other chemicals are carefully chosen to illustrate and highlight the fundamental mechanisms of toxicity at different toxicokinetic and toxicodynamic levels. The book includes references and review articles at the end of each chapter, as well as boxed text for relevant review information on biological, biochemical, molecular, and toxicological background. Linking molecular pathways to more general biomedical contexts, the author ensures that the reader is not lost in the details and instead receives a broad understanding of the processes underlying xenobiotic toxicity.

New in the Second Edition :

Updated chapters

Types of toxic responses

Disruption of signal transduction by xenobiotics

Disruption of mitochondrial function

Novel mechanisms derived from systems toxicology

Urs A. Boelsterli

Introduction, Types of Toxic Responses, Organ-Selective Toxicity, Cellular Transport and Selective Accumulation of Potentially Toxic Xenobiotics, Bioactivation of Xenobiotics to Reactive Metabolites, Xenobiotic-Induced Oxidative Stress: Cell Injury, Signaling, and Gene Regulation, Disruption of Cellular Calcium Homeostasis, Mechanisms of Necrotic and Apoptotic Cell Death, Impairment of Cell Proliferation and Tissue Repair, Covalent Binding of Reactive Metabolites to Cellular Macromolecules, Immune Mechanisms, Cytokine-Mediated Toxicity, Specific Inactivation of Enzymes and Other Proteins, Interactions of Xenobiotics with Ion Transporters, Nuclear Receptor-Mediated Toxicity, Activation or Disruption of Cellular Signal Transduction by Xenobiotics, Disruption of Mitochondrial Function and Mitochondria-Mediated Toxicity, Novel Mechanisms Derived from Systems Toxicology, Index

Erscheinungsdatum	05.09.2017
Verlagsort	London
Sprache	englisch
Maße	156 x 234 mm
Gewicht	453 g
Themenwelt	Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
ISBN-10	1-138-47362-6 / 1138473626
ISBN-13	978-1-138-47362-1 / 9781138473621
Zustand	Neuware