Molecular Basis for the Aging of Human Skin

Buch | Hardcover

240 Seiten

2017
Nova Science Publishers Inc (Verlag)
978-1-5361-2468-2 (ISBN)

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Skin is the most voluminous connective tissue of the body. Skin, like all other human organs, undergoes progressive alterations as a consequence of the passage of time (natural aging). However, human skin, unlike other organs, continuously experiences harmful exposure from environmental sources such as solar ultraviolet irradiation (photoaging). As the bulk of the skin is largely comprised of connective tissue collagen, the primary molecular features of aged human skin are reduced production of collagen and accumulation of damaged collagen. Age-related alterations of dermal connective collagen cause an aberrant tissue microenvironment, which deleteriously influence the risk of developing age-related skin diseases. This book comprehensively describes the molecular mechanisms of human skin connective tissue aging by emphasizing age-related dermal microenvironment as a strategy for improving our quality of life as well as for preventive and therapeutic intervention of age-related skin diseases. This book is an essential resource for the development of mechanisms-based anti-skin aging products.

Preface; Collagen & Human Skin Connective Tissue Aging; Impaired TGF-a Signaling in Aged Human Skin: The Impact on Thin Dermis; Elevated Matrix Metalloproteinases (MMPs) in Aged Human Skin: The Impact on Damaged Dermis; Impaired TGF-a signaling by Age-Related Loss of Fibroblast Size/Shape & Mechanical Tension; Elevated Matrix Metalloproteinases (MMPs) by Age-Related Loss of Fibroblast Size/Shape & Mechanical Tension; CCN Family Proteins in Human Skin Connective Tissue Aging; Oxidative Stress Creates an Age-Associated Dermal Microenvironment (AADM): A Characteristic Feature of Human Skin Connective Tissue Aging; Age-Related Changes in Physical Properties of Dermal Connective Tissue Collagen in Naturally Aged & Photoaged Human Skin; Rejuvenation of Aged Human Skin: The Molecular Basis of Retinol Anti-Aging Properties in Human Skin Connective Tissue Aging; Age-Associated Dermal Microenvironment (AADM) & Age-Related Skin Diseases; Index.

Erscheinungsdatum	07.10.2017
Verlagsort	New York
Sprache	englisch
Maße	155 x 230 mm
Gewicht	394 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Dermatologie
Themenwelt	Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
ISBN-10	1-5361-2468-0 / 1536124680
ISBN-13	978-1-5361-2468-2 / 9781536124682
Zustand	Neuware