Polyploidization and Cancer

Buch | Softcover

151 Seiten

2016 | Softcover reprint of the original 1st ed. 2010
Springer-Verlag New York Inc.
978-1-4939-5143-7 (ISBN)

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Limiting genome replication to once per cell cycle is vital for maintaining genome stability. Although polyploidization is of physiologically importance for several specialized cell types, inappropriate polyploidization is believed to promote aneuploidy and transformation. A growing body of evidence indicates that the surveillance mechanisms that prevent polyploidization are frequently perturbed in cancers. Progress in the past several years has unraveled some of the underlying principles that maintain genome stability. This book brings together leaders of the field to overview
subjects relating to polyploidization and cancer.

Randy Y.C. Poon is a professor of Biochemistry at the Hong Kong University of Science and Technology. He was educated at Tonbridge School and received his Master of Arts degree from St. Catharine’s College at the University of Cambridge. He then studied for a Doctor of Philosophy degree at the University of Cambridge and Cancer Research UK with Tim Hunt, FR S. Dr. Poon conducted postdoctoral training at the Salk Institute with Tony Hunter, FR S. Dr. Poon is a member of Editorial Board of numerous international journals, including the Biochemical Journal and Cancer Biology and Therapy. His research interests focus on understanding the molecular basis of cell cycle control in normal and cancer cells.

Polyploidy, Aneuploidy and the Evolution of Cancer.- Molecular Mechanisms and Function of the Spindle Checkpoint, a Guardian of the Chromosome Stability.- Understanding Cytokinesis Failure.- DNA Damage and Polyploidization.- Role of the p53 Family in Stabilizing the Genome and Preventing Polyploidization.- Centrosomes, Polyploidy and Cancer.- Polyploidy: Mechanisms and Cancer Promotion in Hematopoietic and Other Cells.- Polyploidization of liver cells.- Analysis of Cellular DNA Content by Flow and Laser Scanning Cytometry.

Erscheinungsdatum	19.08.2017
Reihe/Serie	Advances in Experimental Medicine and Biology ; 676
Zusatzinfo	XV, 151 p.
Verlagsort	New York
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete
Themenwelt	Medizin / Pharmazie ► Studium
Schlagworte	Carcinogenesis • Cell • Chromosom • cytokines • DNA • Esophagus • Laser • Liver • proteins • Tumor • Tumorigenesis
ISBN-10	1-4939-5143-2 / 1493951432
ISBN-13	978-1-4939-5143-7 / 9781493951437
Zustand	Neuware