The Immunobiology of H.pylori
Lippincott Williams and Wilkins (Verlag)
978-0-397-58765-0 (ISBN)
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This is a source of information on Helicobacter pylori infection - the host response to infection in the gastrointestinal tract in general, and the immune and inflammatory response to the organism specifically. Every aspect of pathogenesis and the prevention of disease is presented, and divided into four sections: bacterial pathogenesis; induction of host responses; immunopathogenesis of gastroduodenal disease; and induction of gastric immunity. Coverage includes pathogenesis, gastric immunology, immunopathogenesis of gastroduodenal disease, and vaccination. An introductory chapter discusses scientific issues and trends, laying the groundwork for the chapters that follow.
Part 1 Bacterial pathogenesis: the epidemiology of H. pylori-associated gastroduodenal diseases; mporphological cgaracterization of the gastric mucosa during infection with H. pylori; virulence factors produced by H. pylori; the molecular basis for H. pylori adherence and colonization; structure and function of H. pylori urease; VacA and the cag pathogenicity island of H. pylori. Part 2 Induction of host responses: inflammatory responses and intestinal disease in response to bacterial infections; virulence factors of H. pylori and their effects on chemokine production; neutrophil activation by H. pylori; the role of the mononuclear phagocyte in H. pylori-associated infection; T cell selection and epithelial ligands in the gastrintestinal tract; the role of the gastric epithelium in local T cell activation. Part 3 Immunopathogenesis of gastroduodenal disease: aberrant host responses to luminal bacteria in the pathogenesis of chronic intestinal inflammation; regulation of acid secretion and peptic ulcer formation by inflammatory cytokines; the role of nerve-immune interactions in the pathogenesis and prevention. Part 4 Induction of gastric immunity: oral immunization approaches for the prevention of gastrointestinal infections; animal models for vaccine development; oral immunization for the prevention and treatment of infection with helicobacter; changes in immunological effector responses after immunization for H. pylori; strategies for the development of effective H. pylori vaccines.
| Erscheint lt. Verlag | 1.7.1997 |
|---|---|
| Zusatzinfo | 19 halftones, 48 line illustrations, 18 tables |
| Verlagsort | Philadelphia |
| Sprache | englisch |
| Maße | 178 x 254 mm |
| Gewicht | 850 g |
| Themenwelt | Medizinische Fachgebiete ► Innere Medizin ► Gastroenterologie |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin | |
| Studium ► Querschnittsbereiche ► Infektiologie / Immunologie | |
| ISBN-10 | 0-397-58765-1 / 0397587651 |
| ISBN-13 | 978-0-397-58765-0 / 9780397587650 |
| Zustand | Neuware |
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