Portal Hypertension

New Insights

Gerond V Lake-Bakaar (Autor)

Buch | Softcover

100 Seiten

2017
Nova Science Publishers Inc (Verlag)
978-1-5361-2031-8 (ISBN)

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The cirrhotic liver is significantly more vulnerable to injury. This vulnerability is particularly evident after the advent of portal hypertension. In the normal liver, up to 75 percent can be resected without decompensation. By contrast, in the cirrhotic liver with portal hypertension, liver decompensation can occur even after less than 50 percent of the liver is resected. This book begins with an attempt to provide insights into this unanswered puzzle. The normal liver is soft and elastic. By contrast, the cirrhotic liver is inelastic and rigid. Flow in rigid tubes is governed by the Hagen-Poiseuille law. The law dictates that pressure gradient increases exponentially by the fourth power of the radius of the rigid sinusoid. This makes the cirrhotic liver virtually incapable of accommodating any increase in flow. The increase in pressure gradient is equivalent to the fourth power of the vessel radius. The first chapter explores the major new insight that decompensation in the cirrhotic liver is related to the loss of elasticity and the development of vessel wall rigidity, which thereafter subjects flow in the hepatic sinusoids to the Hagen-Poiseuille law. The rest of the book addresses portal hypertension in its clinical context. It invites the reader to survey multiple avenues associated with portal hypertension, including idiopathic non-cirrhotic portal hypertension, INCPH and non-alcoholic fatty liver disease, NAFLD. It also includes chapters on relationships between portal hypertension, the gastrointestinal system and the renal system. In general, the book provides several new insights into portal hypertension.

Gerond V. Lake-Bakaar, M.D., Ph.D. (Liver Center, Beth Israel Deaconess Medical Center, Boston, MA, USA)

Portal Hypertension in Liver Cirrhosis as a Consequence of Sinusoidal Wall Rigidity & Hagen-Poisseuilles Law; Hepatic Steatosis & Portal Hypertension; Unusual Manifestations of Portal Hypertension; Portal Hypertension & the Kidneys; Gastrointestinal Manifestations of Portal Hypertension; Idiopathic Non-Cirrhotic Portal Hypertension; Index.

Erscheinungsdatum	26.08.2017
Verlagsort	New York
Sprache	englisch
Maße	155 x 230 mm
Gewicht	212 g
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Hepatologie
ISBN-10	1-5361-2031-6 / 1536120316
ISBN-13	978-1-5361-2031-8 / 9781536120318
Zustand	Neuware