Network Medicine (eBook)

Complex Systems in Human Disease and Therapeutics

Barabasi Albert-Laszlo Barabasi, Silverman Edwin K. Silverman, Loscalzo Joseph Loscalzo (Herausgeber)

eBook Download: EPUB

2017
500 Seiten
Harvard University Press (Verlag)
978-0-674-54552-6 (ISBN)

Infos

Big data, genomics, and quantitative approaches to network-based analysis are combining to advance the frontiers of medicine as never before. Network Medicine introduces this rapidly evolving field of medical research, which promises to revolutionize the diagnosis and treatment of human diseases. With contributions from leading experts that highlight the necessity of a team-based approach in network medicine, this definitive volume provides readers with a state-of-the-art synthesis of the progress being made and the challenges that remain.Medical researchers have long sought to identify single molecular defects that cause diseases, with the goal of developing silver-bullet therapies to treat them. But this paradigm overlooks the inherent complexity of human diseases and has often led to treatments that are inadequate or fraught with adverse side effects. Rather than trying to force disease pathogenesis into a reductionist model, network medicine embraces the complexity of multiple influences on disease and relies on many different types of networks: from the cellular-molecular level of protein-protein interactions to correlational studies of gene expression in biological samples. The authors offer a systematic approach to understanding complex diseases while explaining network medicine's unique features, including the application of modern genomics technologies, biostatistics and bioinformatics, and dynamic systems analysis of complex molecular networks in an integrative context.By developing techniques and technologies that comprehensively assess genetic variation, cellular metabolism, and protein function, network medicine is opening up new vistas for uncovering causes and identifying cures of disease.

Produkt-Details

• Erscheint lt. Verlag: 1.2.2017
• Co-Autor: Leroy Arnaud Leroy, Luke Douglas Luke, Antman Elliott M. Antman, Weinstock George M. Weinstock, Lippens Guy Lippens, Kitano Hiroaki Kitano, Huvent Isabelle Huvent, Landrieu Isabelle Landrieu, Eddy James A. Eddy, Gunawardena Jeremy Gunawardena, Lasky-Su Jessica Lasky-Su, Litonjua Augusto A. Litonjua, Sordillo Joanne E. Sordillo, Earls John C. Earls, Quackenbush John Quackenbush, Menche Jorg Menche, Glass Kimberly R. Glass, Vidal Marc Vidal, Schoen Martin W. Schoen, Calderwood Michael A. Calderwood, Cusick Michael E. Cusick, Price Nathan Price, Parent Benjamin Parent, Ghosh Samik Ghosh, Weiss Scott Tillman Weiss, Ma Shuyi Ma, Palaniappan Sucheendra K. Palaniappan, Prabakaran Sudhakaran Prabakaran, Rolland Thomas Rolland, Charloteaux Benoit Charloteaux, MacRae Calum A. MacRae, Smet-Nocca Caroline Smet-Nocca, Clish Clary B. Clish, Hill David E. Hill, Demeo Dawn Lisa Demeo
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
• ISBN-10: 0-674-54552-4 / 0674545524
• ISBN-13: 978-0-674-54552-6 / 9780674545526