Oncoscint Cancer Imaging
Marcel Dekker Inc (Verlag)
978-0-8247-8646-5 (ISBN)
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This volume discusses the preclinical and clinical experience with the B72.3 monoclonal anti-body as a tumour targeting agent - emphasizing the results of studies utilizing site-specifically radiolabelled B72.3 (CYT-103-111In; OncoScint CR103). Focusing on OncoStint's ability to determine the presence and extent of disease in colorectal or ovarian cancer patients, this book: reviews the generation of the B72.3 monoclonal antibody and its development from preclinical trials to the first approved cancer imaging technology; presents the results of clinical trials of radioiodinated and indium-111 labelled material for colorectal cancer patients and considers the contribution of this procedure to their care; describes the use of CYT-103-111In as a presurgical diagnostic agent in ovarian cancer patients and its impact on their surgical management; and offers examples of normal biodistribution, tumour localization, and the potential pitfalls in image interpretation. The book is intended for radiologists, internists, oncologists, nuclear medicine physicians, gastroenterologists, obstetricians/gynaecologists, immunologists and surgeons.
An overview of radioimmunoimaging, Samuel Halpern; generation and characterization of monoclonal antibody B72.3 - experimental and preclinical studies, David Colcher, et al; imaging of colorectal carcinoma with iodine-131 B72.3 monoclonal antibody, Jorge A. Carrasquillo; monoclonal antibody B72.3 immunoscintography in the follow-up of patients with colorectal cancer, Secondo Lastoria and Marco Salvatore; multicentre clinical trials of monoclonal antibody B72.3- GYK-DTPA-111In (CYT-103-111/in; oncoscint CR103) in patients with colorectal carcinoma, Hani Abdel-Nabi and Ralph J. Doerr; oncoscint CR-103 imaging in the surgical management of patients with colorectal cancer, Ralph J. Doerr and Hani Abdel-Nabi; multicentre clinical trial of 111In-CYT-103 in patients with ovarian cancer, Donald G. Gallup; impact of 111In-CYT 103 imaging on the surgical management of patients with ovarian cancer, Earl A. Surwit; oncoscint image atlas, Robert T. Maguire; immunopharmacokinetics of 111In-CYT-103 in ovarian cancer patients, William J. Jusko, et al; a practical approach to planar and SPECT imaging of indium-111 CYT-103, B. David Collier, et al; future directions in tumour radioimmunodetection, Thomas J. McKearn.
| Reihe/Serie | Targeted Diagnosis & Therapy Series ; v. 6 |
|---|---|
| Zusatzinfo | illustrations, colour photographs |
| Verlagsort | New York |
| Sprache | englisch |
| Maße | 159 x 241 mm |
| Gewicht | 544 g |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Gynäkologie / Geburtshilfe |
| Medizinische Fachgebiete ► Innere Medizin ► Gastroenterologie | |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie | |
| Medizinische Fachgebiete ► Radiologie / Bildgebende Verfahren ► Nuklearmedizin | |
| Studium ► 1. Studienabschnitt (Vorklinik) ► Histologie / Embryologie | |
| Studium ► Querschnittsbereiche ► Infektiologie / Immunologie | |
| ISBN-10 | 0-8247-8646-7 / 0824786467 |
| ISBN-13 | 978-0-8247-8646-5 / 9780824786465 |
| Zustand | Neuware |
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