Reduction of Sporadic Malignancies by Stimulation of Cellular Repair Systems & by Targeting Cellular Energy Metabolism

Borut Poljsak, Thomas N Seyfried, Dominic P DAgostino, Angela M Poff, Irina Milisav (Autoren)

Buch | Softcover

70 Seiten

2017
Nova Science Publishers Inc (Verlag)
978-1-5361-0773-9 (ISBN)

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About 40% of the population in the industrialised world will develop cancer at some point in their lives, and about half of these people will be cured. Unfortunately, however, approximately one in four Americans alone will die from cancer (over 560,000 Americans each year). Tomasetti and Vogelstein have recently reported that nearly two-thirds of all cancers are caused by random mutations of the body's stem cells. The more random mutations accumulate, the higher the risk of unchecked cell growth, which is a hallmark of cancer development. Knowing the causes of the tumour formation should allow for the development of preventative measures. But what if a tumour is formed due to random mutations during the individuals lifetime? Are there any preventive methods aside from early detection? Reducing the amount of replicative errors must decrease the accumulation rate of random mutations. In this book, the authors provide an overview of approaches that could influence the formation of cancers caused by random mutations, with a focus on methods aimed at modulating genomic stability and/or strengthening the damage repair processes. Targeting cell metabolism through exposure to moderate stress induced by caloric restriction, physical activity or mimetic compounds can activate endogenous defence mechanisms and cellular repair processes.

Preface; Introduction; Mutation Rate Chance and Theories of Mutation; Signaling Pathways Important for Cellular Metabolism, Damage Repair and Defense; Conclusion.

Erscheinungsdatum	02.02.2017
Verlagsort	New York
Sprache	englisch
Maße	155 x 230 mm
Gewicht	158 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
ISBN-10	1-5361-0773-5 / 1536107735
ISBN-13	978-1-5361-0773-9 / 9781536107739
Zustand	Neuware