The Design and Analysis of Sequential Clinical Trials
Seiten
1997
|
Revised, 2nd Edition
John Wiley & Sons Inc (Verlag)
978-0-471-97550-2 (ISBN)
John Wiley & Sons Inc (Verlag)
978-0-471-97550-2 (ISBN)
In sequential clinical trials, data from patients treated at the beginning of a trial can be analyzed while the trial is still in progress and subsequent patients can be recruited. This analysis provides stopping rules whereby the number of patients involved can be limited without affecting the results.
This book details all aspects of sequential clinical trials from preliminary planning, through the monitoring of the trial, to the final analysis of the results. Emphasis is placed on the triangular test and other procedures based on straight line stopping boundaries. These methods allow for frequent or occasional interim analyses and permit the analysis of a wide variety of patient responses. Alternative procedures are also covered in detail, and these include -spending function methods, repeated confidence intervals and Bayesian approaches to sequential clinical trials.
This book details all aspects of sequential clinical trials from preliminary planning, through the monitoring of the trial, to the final analysis of the results. Emphasis is placed on the triangular test and other procedures based on straight line stopping boundaries. These methods allow for frequent or occasional interim analyses and permit the analysis of a wide variety of patient responses. Alternative procedures are also covered in detail, and these include -spending function methods, repeated confidence intervals and Bayesian approaches to sequential clinical trials.
John Whitehead is the author of The Design and Analysis of Sequential Clinical Trials, Revised, 2nd Edition, published by Wiley.
Clinical Trials.
Allocating Patients to Treatments.
Measurement of Treatment Difference.
The Design of a Sequential Trial Using the Boundaries Approach.
The Analysis of a Sequential Trial.
Alternative Approaches to the Design and Analysis of Sequential Clinical Trials.
Prognostic Factors.
The Comparison of More than Two Treatments.
Implementation of Sequential Methods: Some Examples.
References.
Appendix.
Index.
| Erscheint lt. Verlag | 25.6.1997 |
|---|---|
| Reihe/Serie | Statistics in Practice |
| Verlagsort | New York |
| Sprache | englisch |
| Maße | 165 x 240 mm |
| Gewicht | 624 g |
| Themenwelt | Mathematik / Informatik ► Mathematik ► Wahrscheinlichkeit / Kombinatorik |
| Studium ► Querschnittsbereiche ► Epidemiologie / Med. Biometrie | |
| ISBN-10 | 0-471-97550-8 / 0471975508 |
| ISBN-13 | 978-0-471-97550-2 / 9780471975502 |
| Zustand | Neuware |
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