Molecular Histopathology and Tissue Biomarkers in Drug and Diagnostic Development
Humana Press Inc. (Verlag)
978-1-4939-5420-9 (ISBN)
Comprehensive and practical, Molecular Histopathology and Tissue Biomarkers in Drug and Diagnostic Development will inform and enlighten both tissue-focused and non-tissue-focused drug development professionals about better use and interpretation of the multidimensional data contained in a tissue biopsy.
Histopathology: A Canvas and Landscape of Disease in Drug and Diagnostic Development.- A Field Guide to Homo morphologicus for Biomedical Scientists, Or How to Convey an Understanding of Pathology to Scientists in a Biopharma Enterprise.- Outsourcing Tissue Histopathology Investigations in Support of Clinical Trials for Novel Therapeutics: Considerations and Perspectives.- Histopathology in Mouse Models of Rheumatoid Arthritis.- Markers Used for Visualization and Quantification of Blood Vessels and Lymphatic Vessels.- Practical Approaches to Microvessel Analysis: Hotspots, Microvessel Density, and Vessel Proximity.- Quantitative Histopathology and Alternative Approaches to Assessment of Fibrosis for Drug Development in Hepatitis C and Nonalcoholic Steatohepatitis.- Stereology and Computer-Based Image Analysis Quantifies Heterogeneity and Improves Reproducibility for Grading Reticulin in Myeloproliferative Neoplasms.- Image Analysis Tools for Quantification of Spinal Motor Neuron Subtype Identities.- Development of a Tissue Image Analysis Algorithm for Celiac Drug Development.- Quantitative Histopathology for Evaluation of In Vivo Biocompatibility Associated with Biomedical Implants.- Quantitative Histomorphometry and Quantitative Polymerase Chain Reaction (PCR) as Assessment Tools for Product Development.- Measuring the Messenger: RNA Histology in Formalin Fixed Tissues.- Algorithm-Driven Image Analysis Solutions for RNA ISH Quantification in Human Clinical Tissues.- Solid Tissue-Based DNA Analysis by FISH in Research and Molecular Diagnostics.- Preanalytic Considerations for Molecular Genomic Analyses of Tissue.- Next Generation Sequencing (NGS) in Anatomic Pathology Discovery and Practice.- The Impact of Pre-Analytic Variables on Tissue Quality from Clinical Samples Collected in a Routine Clinical Setting: Implications for Diagnostic Evaluation, Drug Discovery, and Translational Research.- Adapting HER2 Testing for a Different Organ: New Wine in Old Wineskins.- Tissue-Based Companion Diagnostics: Development of IHC Assays from an Industry Perspective.- Development of Tissue-Based Companion Diagnostics: The Relationship Between the Pharmaceutical Company, Diagnostic Partner, and the Biomarker Laboratory.- Navigating Regulatory Approval for Tissue-Based Companion Diagnostics.- Implementing a Multi-Analyte Immunohistochemistry Panel into a Drug Development Program.- Cutpoint Analysis and Related Statistical Methods in Digital Pathology and Companion Diagnostics.
Erscheinungsdatum | 04.11.2016 |
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Reihe/Serie | Methods in Pharmacology and Toxicology |
Zusatzinfo | 37 Illustrations, color; 20 Illustrations, black and white; XVIII, 375 p. 57 illus., 37 illus. in color. |
Verlagsort | Totowa, NJ |
Sprache | englisch |
Maße | 178 x 254 mm |
Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie |
Medizin / Pharmazie ► Pharmazie | |
Schlagworte | Biopharma • Companion diagnostics • Flagship Biosciences • Histology • Initial New Drug Application (IND) • In situ Hybridization • Pathology • pharmaceutical research • Pharmazie • Tissue analysis • Tissue biopsy |
ISBN-10 | 1-4939-5420-2 / 1493954202 |
ISBN-13 | 978-1-4939-5420-9 / 9781493954209 |
Zustand | Neuware |
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