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Advances in Heterocyclic Chemistry

Istvan Hermecz, etc., Geza Kereszturi, Lelle Vasvari-Debreczy (Herausgeber)

Buch | Hardcover

452 Seiten

1992
Academic Press Inc (Verlag)
978-0-12-020754-1 (ISBN)

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Part of a serial, this volume is intended for organic and medicinal chemists. Features include references and an index, and a cumulative subject index for Volumes 46 - 54.

This volume surveys the chemistry and heterocyclic syntheses of aminomethylenemalonates and their cyclic sters. Early reviews in this field merely touched on certain aspects of the related chemistry. This is the first in-depth systematic treatment of the subject. The material is of particular importance in medicinal chemistry as derivatives of aminomethylene malonates are key intermediates in the synthesis of antimalarial agents. The literature reviewed has led to the discovery of nalidixic acid and its derivatives, norfloxacin and ciprofloxacin, as well as the new quinolones that are active against AIDS-related Legionella spp.

Work in the 19th century; structure of aminomethylenemalonates. Part 1 Syntheses: sytheses of kialkly 1-aminoalkylidenemalonates; syntheses of alkylidene 1-aminoalkylidenemalonates; syntheses of 2-azacycloalkylidenemalonates. Part 2 Cyclization of 1-aminoalkylidenemalonates: cyclization of dialkyl aminoalkylidenemalonates; cyclization of alkylidene aminomethylenemalonates; cyclization of azacycloalkylidenemalonates; further ring closure. Part 3 Other reaction of aminomethylenemalonates: reactions of dialkyl 1-aminoalkylidenemalonates;reactions of alkylidene aminomethylenemalonates; reaction of 2-azacycloalkylidenemalonates; miscellaneous methods; recent research appendix.

Reihe/Serie	Advances in Heterocyclic Chemistry ; Vol 54
Zusatzinfo	references, index
Verlagsort	San Diego
Sprache	englisch
Gewicht	807 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
Themenwelt	Naturwissenschaften ► Chemie ► Organische Chemie
ISBN-10	0-12-020754-0 / 0120207540
ISBN-13	978-0-12-020754-1 / 9780120207541
Zustand	Neuware