Pre-Analytics of Pathological Specimens in Oncology

Manfred Dietel, Christian Wittekind, Gianni Bussolati, Moritz Winterfeld (Herausgeber)

Buch | Softcover

VI, 133 Seiten

2016 | 1. Softcover reprint of the original 1st ed. 2015
Springer International Publishing (Verlag)
978-3-319-34982-4 (ISBN)

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This book presents an overview of the most important current developments in the pre-analytical handling of tissue. It addresses in particular potential ways to improve the situation whereby methods employed in the pre-analytical phase - the period from surgical removal of tissue to the start of pathological processing - have remained essentially unchanged for decades with only modest standardization. It is examined how the pre-analytical period can be optimized, resulting not only in an increase in diagnostic quality but also in a reduction in processing time and costs. Among the key topics examined are the so-called cold ischemia time between tissue removal and fixation, the potential superiority of vacuum-based preservation over immediate formalin fixation, two-temperature fixation, molecular analysis methods, and the pre-analytics of specimens from particular tissues. Readers will find this book to be an important update that reveals the full importance of the pre-analytical phase for quality of pathological work-up.

What Is Pre-Analytics in Surgical Pathology? .- Histologic Validation of Vacuum Sealed Formalin.- Free Tissue Preservation and Transport System .- Pre-Analytics and Molecular Pathology.- Experiences in Vacuum Preparation of Routine Specimens.- Tissue Heterogeneity as a Pre-Analytical Source of Variability.- Vacuum Fixation of Breast Specimens Before Grossing.- How Do Short Fixation and Rapid Microwave Processing Affect Her2 Testing?.- Current Projects in Pre-Analytics - Where to Go?.- Nucleic Acid Extraction from FFPE Tissue as Critical Preanalytic Step for NGS Applications.- Experiences With Pre-Analytics of Lung Specimen.- Experiences With Pre-Analytics of GI-Specimen.- Bone Marrow Work-Up.- Two-Temperature Fixation Preserves Activation Status with High Efficiency.- Towards the Lean Lab. The Industry Challenge.

Erscheinungsdatum	14.10.2016
Reihe/Serie	Recent Results in Cancer Research
Zusatzinfo	VI, 133 p. 65 illus., 61 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
Schlagworte	Cold Ischemia Time • laboratory medicine • Medical laboratory testing and techniques • Medicine • Medicine: general issues • Molecular Analysis Methods • Oncology • Pathology • Preservation of Tissue • Surgery • Two-Temperature Fixation • Vacuum-based Preservation
ISBN-10	3-319-34982-1 / 3319349821
ISBN-13	978-3-319-34982-4 / 9783319349824
Zustand	Neuware