Monoclonal Antibodies
Hodder Arnold (Verlag)
978-0-412-41090-1 (ISBN)
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Since its discovery in 1975 the monoclonal antibody has become a powerful weapon in the clinical application of molecular biology. Antibodies can now be linked to novel diagnostic and therapeutic molecules in many fields of medicine, including cancer. This book examines the role of monoclonal antibodies in clinical oncology by covering new developments in the field. Its aim is to increase understanding of the applications and potential of monoclonals. The 36 chapters in this volume are written by an international group of leading experts working with monoclonal antibodies. The contributors are specialists in molecular biology, chemistry, medical physics, immunology, histopathology, nuclear medicine and clinical oncology. This book should be of interest to oncologists, radiologists, immunologists.
In vitro immunization of mouse spleen cells using protein and peptide antigens; immunodiagnosis of pancreatic cancers; idiotypic approach to the production of monoclonal antibodies against a human tumour-associated antigen; biochemical and biological characterization of the mouse/human chimaeric MBr1; reshaping of human antibodies using CDR-grafting; human antibodies and host recognition of ovarian carcinoma antigens; antireceptor antibody structure and peptide design; expression of antibody-ricin A chain fusions in mammalian cells; dosimetry of radiolabelled antibodies; radioimmunoimaging of squamous cell carcinoma; enhancement of tumour dose via antibody radiohalogenation; improved MB-1 delivery to lymphoma by predosing; intraperitoneal dosimetry of radiolabelled antibodies; biodistribution of polylysire guided radionuclides; monoclonal antibody uptake and distribution following intratumour injection; Indium-111 and Yttrium-90 labelled macrocyclic chelating agents; generation of bispecific monoclonal antibodies for two-phase radio-immunotherapy; cytotoxicity following specific activation of amygdalon; endogenous activation of a proding in antibody-directed enzyme proding therapy; application of matrix-conjugated monoclonal antibodies in enzyme isolation and analysis; evaluation of CA-549 in breast cancer; monoclonal antibodies; 323/A3 expression in potassium cysts of the breast; tamoxifen and oestradiol-regulated 24K protein expression; the role of radiolabelled antibodies in cancer diagnosis; hand-guided probes in intrasurgical radioimmunodetection; localization and immunohistochemistry of human gliomas using MUC 2-63; antibody uptake non-small cell lung cancer following irradiation; monoclonal antibody uptake by bladder carcinomas following intravesical administration; intraperitoneal radioimmunotherapy with stable Yttrium-90-labelled immunoconjugates; T cell proliferation following monoclonal antibody treatment; anti-idiotypes in cancer immunotherapy; chimeric monoclonal antibody studies in colorectal cancer; early clinical results with 99cm Tc-labelled F(ab)2; lymphoscintigraphy with recombinant epidermal-growth-factor in uterine cervical cancer.
| Erscheint lt. Verlag | 4.9.1998 |
|---|---|
| Zusatzinfo | 100 illustrations |
| Verlagsort | London |
| Sprache | englisch |
| Maße | 189 x 246 mm |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie |
| Medizinische Fachgebiete ► Radiologie / Bildgebende Verfahren ► Nuklearmedizin | |
| Studium ► Querschnittsbereiche ► Infektiologie / Immunologie | |
| ISBN-10 | 0-412-41090-7 / 0412410907 |
| ISBN-13 | 978-0-412-41090-1 / 9780412410901 |
| Zustand | Neuware |
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