TRP Channels in Drug Discovery

Volume II

Arpad Szallasi, Tamás Bíró (Herausgeber)

Buch | Softcover

489 Seiten

2016 | Softcover reprint of the original 1st ed. 2012
Humana Press Inc. (Verlag)
978-1-4939-6066-8 (ISBN)

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Recent findings have implied a distinct therapeutic potential for drugs targeting Transient Receptor Potential (TRP) channels in a wide variety of diseases, many with no existing satisfactory treatment options. Thus, the TRP superfamily of ion channels has attracted a great deal of well-deserved attention. TRP Channels in Drug Discovery provides a thorough collection of the most up-to-date reviews and protocols on the subject, coming from top experts in the field. Volume II presents practical methodologies involving models for disorders of the cardiovascular system, the brain, skin, the metabolic system, as well as colitis, cancer, thermosensation, and musculoskeletal disorders. Written for the Methods in Pharmacology and Toxicology™ series, this work includes the kind of detailed description and key implementation advice that ensures successful results in the lab.

Comprehensive and cutting-edge, TRP Channels in Drug Discovery serves as an ideal reference for graduate students in academic laboratories as well as for pharmaceutical scientists developing new drugs and clinicians interested in novel drugs in the pipeline.

TRPs to Cardiovascular Disease.- Anemic Zebrafish Models of Cardiomyopathy.- Methods to Study the Effects of TRP Channel Drugs on Vascular Endothelial Cell Function.- Atherosclerosis Models with Cell-Mediated Calcification.- Models of Hypertension and Blood Pressure Recording.- Balloon Injury in Rats as a Model for Studying TRP Channel Contribution to Vascular Smooth Muscle Remodeling.- TRP Channels in the Brain.- Investigation of the Possible Role of TRP Channels in Schizophrenia.- Investigating Diseases of Dopaminergic Neurons and Melanocytes Using Zebrafish.- A Practical Guide to Evaluating Anxiety-Related Behavior in Rodents.- Rodent Models of Conditioned Fear: Behavioral Measures of Fear and Memory.- Chick Anxiety-Depression Screening Model.- A Clinically Relevant Thromboembolic Stroke Model in the Aged Rat.- Use of Cell-Stretch System to Examine the Characteristics of Mechanosensor Channels: Axonal Growth/Neuroregeneration Studies.- Methods in Neuronal Growth Cone Biology.- Transient Receptor Potential Channels and Pruritus.- Skin Sensitivity Studies.- Hair Follicle Culture.- Animal Models for Type 1 Diabetes.- Type 2 Diabetes Models.- Using Diet to Induce Metabolic Disease in Rodents.- Rodent Models to Evaluate Anti-Obesity Drugs.- Experimental Colitis Models.- Tumor Xenograft Models to Study the Role of TRP Channels in Tumorigenesis.- Methods to Study Thermonociception in Rodents.- Methods for the Assessment of Heat Perception in Humans.- Collagen Antibody-Induced Arthritis (CAIA): A Disease-Relevant Model for Studies of Persistent Joint Pain.- Animal Models of Muscular Dystrophy.

Erscheinungsdatum	24.07.2016
Reihe/Serie	Methods in Pharmacology and Toxicology
Zusatzinfo	XIV, 489 p.
Verlagsort	Totowa, NJ
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pflege
	Medizin / Pharmazie ► Pharmazie ► PTA / PKA
	Naturwissenschaften ► Biologie ► Biochemie
ISBN-10	1-4939-6066-0 / 1493960660
ISBN-13	978-1-4939-6066-8 / 9781493960668
Zustand	Neuware