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Ex Vivo Engineering of the Tumor Microenvironment

Amir R. Aref, David Barbie (Herausgeber)

Buch | Hardcover

IX, 135 Seiten

2016 | 1st ed. 2017
Springer International Publishing (Verlag)
978-3-319-45395-8 (ISBN)

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This volume will outline how to recreate the tumor microenvironment, to culture primary tumors without the need for developmental priming factors, and to deliver targeted therapeutics in a manner that recapitulates pharmacokinetics in vivo . Much of what may be learned from this volume will aid in understanding many aspects of the enhanced study of tumor cell biology in a physiologic context, open new avenues for drug screening and biomarker development, and accelerate the preclinical evaluation of novel personalized medicine strategies for patients in real time.

Amir R. Aref, PhD, is Instructor, Dana-Farber Cancer Institute, Harvard Medical School.

1.Introduction to Ex Vivo Cancer Models.- 2.Patient-derived Xenografts in Oncology.- 3.Organoid Culture: Applications in Development and Cancer.- 4.Microfluidics and future of cancer diagnostics.- 5.Advancing techniques and insights in circulating tumor cell (CTC) research.- 6.The Cancer Secretome.- 7.An overview of the tumor microenvironments and future of cancer therapy.

Erscheinungsdatum	06.01.2017
Reihe/Serie	Cancer Drug Discovery and Development
Zusatzinfo	IX, 135 p. 18 illus., 17 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
Themenwelt	Medizin / Pharmazie ► Studium
Schlagworte	Cancer Research • Ex vivo • Medicine • Oncology • reconstruction • solid tumors • therapeutics • Tumor
ISBN-10	3-319-45395-5 / 3319453955
ISBN-13	978-3-319-45395-8 / 9783319453958
Zustand	Neuware