Tumor Microenvironment and Cellular Stress

Signaling, Metabolism, Imaging, and Therapeutic Targets

Constantinos Koumenis, Ester Hammond, Amato Giaccia (Herausgeber)

Buch | Softcover

290 Seiten

2016 | Softcover reprint of the original 1st ed. 2014
Springer-Verlag New York Inc.
978-1-4939-4705-8 (ISBN)

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The collection of chapters in this proceeding volume reflects the latest research presented at the Aegean meeting on Tumor Microenvironment and Cellular Stress held in Crete in Fall of 2012. The book provides critical insight to how the tumor microenvironment affects tumor metabolism, cell stemness, cell viability, genomic instability and more. Additional topics include identifying common pathways that are potential candidates for therapeutic intervention, which will stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery.

Constantinos Koumenis, Ph.D. is an Associate Professor, Vice Chair and Research Division Director and Co-Leader, Radiation Biology & Imaging Program at the University of Pennsylvania, School of Medicine. Amato Giacca,Ph.D., is a Professor and Director of the Department of Radiation Oncology, Leader of Radation Biology and Molecular Therapeutics Program at the Stanford Cancer Center. Ester Hammond Ph.D., is a Junior Group Leader at Gray Institute for Radiation Oncology and Biology at Oxford University.

Introduction.- Hypoxia and metabolism in cancer.- Hypoxia and Regulation of Cancer Cell Stemness.- Hypoxia-mediated metastasis.- Escape Mechanisms from Antiangiogenic Therapy: An Immune Cell’s Perspective.- Hypoxic VDAC1: a potential mitochondrial marker for cancer therapy.- Hypoxia directed drug strategies to target the tumor microenvironment.- Radiotherapy and the Tumor Microenvironment: Mutual Influence and Clinical Implications.- Autophagy and cell death to target cancer cells: exploiting synthetic lethality as cancer therapeutic.- Intratumoral Hypoxia as the Genesis of Genetic Instability and Clinical Prognosis in Prostate Cancer.- miR-210: Fine-Tuning the Hypoxic Response.- The role of complement in tumor growth.- Imaging angiogenesis, inflammation and metastasis in the tumor microenvironment with magnetic resonance imaging.- Index.

Erscheinungsdatum	22.09.2016
Reihe/Serie	Advances in Experimental Medicine and Biology ; 772
Zusatzinfo	30 Illustrations, color; 8 Illustrations, black and white; X, 290 p. 38 illus., 30 illus. in color.
Verlagsort	New York
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
Schlagworte	drug discovery • Hypoxia • microenvironment • therapy • Tumor
ISBN-10	1-4939-4705-2 / 1493947052
ISBN-13	978-1-4939-4705-8 / 9781493947058
Zustand	Neuware