Arrestins - Pharmacology and Therapeutic Potential

Buch | Softcover

VIII, 447 Seiten

2016 | 1. Softcover reprint of the original 1st ed. 2014
Springer Berlin (Verlag)
978-3-662-52299-8 (ISBN)

Artikel merken

This volume in Springer's authoritative series on experimental pharmacology covers the molecular mechanisms and therapeutic implications of arrestin-mediated signaling, including the potential of re-engineered signaling proteins in the field of gene therapy.

This volume describes our current understanding of the biological role of visual and non-visual arrestins in different cells and tissues, focusing on the mechanisms of arrestin-mediated regulation of GPCRs and non-receptor signaling proteins in health and disease. The book covers wide range of arrestin functions, emphasizing therapeutic potential of targeting arrestin interactions with individual partners.

Therapeutic Potential of Small Molecules and Engineered Proteins.-Arrestin Interactions with G Protein-coupled Receptors.- Arrestin-biased GPCR Agonists.- Arrestin-1 Expression Levels, Rod Function and Health.- Protective Functions of Arrestin-1 in Photoreceptors.- Arrestin-4 and Cone Function.- Enhanced Phosphorylation-independent Arrestins and Gene Therapy.- Targeting Particular Receptors with Redesigned Non-visual Arrestins.- Arrestins binding to clathrin, AP2 and Role in GPCR trafficking.- Arrestins in Ubiquitination and Deubiquitination.- Arrestin Self-association.- Arrestin-dependent Activation of ERK and Src.- Arrestin-dependent Activation of JNK Family Kinases.- Arrestin-Mediated P38 Activation.- Arrestin-dependent PDE Localization.- Arrestins in Cell Migration.- Arrestins in Host-pathogen Interactions.- Arrestin Regulation of Small GTPases.- GPCRs and Arrestins in Airways: Implications for Asthma.- Arrestins as Regulatory Signaling Hubs in Cancer Pathways.- Arrestins in Pain and Anesthesia.

Erscheinungsdatum	20.08.2016
Reihe/Serie	Handbook of Experimental Pharmacology
Zusatzinfo	VIII, 447 p. 53 illus., 42 illus. in color.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
Themenwelt	Medizin / Pharmazie ► Pharmazie
Schlagworte	Apoptosis • arrestin • biochemistry • Biochemistry, general • Biomedical and Life Sciences • cell physiology • cell signaling • cellular biology (cytology) • gene therapy • G protein-coupled receptors • MAP Kinases • pharmacology • Pharmacology/Toxicology • Proliferation • Protein Structure • receptors
ISBN-10	3-662-52299-3 / 3662522993
ISBN-13	978-3-662-52299-8 / 9783662522998
Zustand	Neuware