The Genetics of Renal Tract Disorders
Seiten
1988
Oxford University Press (Verlag)
978-0-19-261147-5 (ISBN)
Oxford University Press (Verlag)
978-0-19-261147-5 (ISBN)
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`This text will be welcomed by clinicians and will also be an excellent source of reference for geneticists and pathologists.' The Lancet .
The Genetics of Renal Tract Disorders provides a comprehensive account of both the hereditary nephropathies and more generalized disorders which may affect the renal tract. The book opens with introductory chapters on renal anatomy, embryology, and physiology for the geneticist, and on human inheritance for the nephrologist. Subsequent chapters each deal with one aspect of renal tract disorders - the chapter on primary hereditary nephropathies includes an extensive discussion of Alport's disease and hereditary nephritis without deafness. Within the chapters, each section gives a brief description of the clinical and pathological features of a particular disorder, emphasizing the renal aspects of those disorders that are not primarily renal. This is followed by a review of the genetics of the disorder including incidence, inheritance of familial occurrence, genetic linkage and gene assignment, and prenatal diagnosis and carrier detection. Where there is evidence for genetic heterogeneity this is discussed. Original studies are extensively quoted and are referenced at the end of each section. There are a great many dysmorphic syndromes which involve the urinary tract.
These are incorporated within the relevant sections of the book and are listed in the index. Nephrologists and urologists; clinicians with an interest in renal disease in both adults and children; clinical geneticists; paediatricians.
The Genetics of Renal Tract Disorders provides a comprehensive account of both the hereditary nephropathies and more generalized disorders which may affect the renal tract. The book opens with introductory chapters on renal anatomy, embryology, and physiology for the geneticist, and on human inheritance for the nephrologist. Subsequent chapters each deal with one aspect of renal tract disorders - the chapter on primary hereditary nephropathies includes an extensive discussion of Alport's disease and hereditary nephritis without deafness. Within the chapters, each section gives a brief description of the clinical and pathological features of a particular disorder, emphasizing the renal aspects of those disorders that are not primarily renal. This is followed by a review of the genetics of the disorder including incidence, inheritance of familial occurrence, genetic linkage and gene assignment, and prenatal diagnosis and carrier detection. Where there is evidence for genetic heterogeneity this is discussed. Original studies are extensively quoted and are referenced at the end of each section. There are a great many dysmorphic syndromes which involve the urinary tract.
These are incorporated within the relevant sections of the book and are listed in the index. Nephrologists and urologists; clinicians with an interest in renal disease in both adults and children; clinical geneticists; paediatricians.
Mechanisms of human inheritance; Structure and function of the renal tract; Urinary tract anomalies in chromosomal disorders; Inherited metabolic diseases involving the kidney; Urolithiasis and crystalluria; Renal tubular (transport) defects; Primary hereditary nephropathies; Nephropathy secondary to systemic disorders; Cystic kidneys: definition and classificaion; Renal tract malformations; Urinary tract infections; Renal tract neoplasias.
| Reihe/Serie | Oxford Monographs on Medical Genetics |
|---|---|
| Zusatzinfo | Ill.figs.tabs. |
| Verlagsort | Oxford |
| Sprache | englisch |
| Maße | 160 x 240 mm |
| Gewicht | 1277 g |
| Themenwelt | Medizinische Fachgebiete ► Innere Medizin ► Nephrologie |
| Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik | |
| ISBN-10 | 0-19-261147-X / 019261147X |
| ISBN-13 | 978-0-19-261147-5 / 9780192611475 |
| Zustand | Neuware |
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