Diagnostic Pathology: Blood and Bone Marrow

Kathryn Foucar, Devon Chabot-Richards, David R. Czuchlewski, Kristin Hunt Karner, Kaaren K. Reichard (Autoren)

Buch | Hardcover

976 Seiten

2018 | 2nd edition
Elsevier - Health Sciences Division (Verlag)
978-0-323-39254-9 (ISBN)

Infos

Part of the highly regarded Diagnostic Pathology series, Diagnostic Pathology: Blood and Bone Marrow, second edition includes today's most recent knowledge on the latest finds in this subspecialty. New chapters focus on current molecular insights into the pathogenesis of familial disorders and neoplasms, ensuring pathologists, hematopathologists, hematologists, and oncologists alike can deliver the most up-to-date diagnoses possible. Concise, bulleted text coupled with extensive illustrations makes this succinct yet comprehensive reference ideal for clinical use.



Expert Consult eBook version included, which allows you to search all of the text, figures, and references from the book on a variety of devices
Includes an introductory chapter on the basics of hematopathology, such as a review of normal peripheral blood and bone marrow histology, flow charts of hematopoiesis, photomicrographs of the various stages of each lineage, and descriptions of the common stains used in hematopathology
Multiple new chapters focus on current molecular insights into the pathogenesis of familial disorders and neoplasms
Features a new chapter on familial leukemia propensity disorder



Content covers many of today's hot topics, incorporating the recently published WHO criteria in the Revised 4th Edition WHO Classification of Tumours of Hematopoietic and Lymphoid Tissues (IARC, Lyon, 2017), novel genetic subtypes of acute lymphoblastic leukemia, multiple new lymphoma subtypes, clinical practice guidelines for diagnosis of acute leukemias, and hematologic problems of the elderly
Pinpoints important elements in the diagnosis of benign and neoplastic disorders
Clearly delineates numerous genetic disorders often found in blood and bone marrow
Ideal for trainees seeking basic information as well as experienced practitioners in need of a brief refresher

Autor

Dr. Kathy Foucar is a Distinguished Professor Emerita of Pathology at the University of New Mexico Health Sciences Center with 40+ years of practice in diagnostic hematopathology. She is the cofounder of the Hematopathology Fellowship at UNM. Dr. Foucar is the author or editor of 13 books on neoplastic and non-neoplastic hematopathology with an emphasis on blood and bone marrow, and over 120 peer-reviewed publications. She is the 2019 recipient of the Alumni Achievement Award from Ohio State University School of Medicine. Devon Chabot-Richards, MD, is Associate Professor with the Department of Pathology at The University of New Mexico Health Sciences Center. Dr. Chabot-Richards is also Medical Director of Molecular Oncology Laboratory at TriCore Reference Laboratories in Albuquerque, New Mexico Mohammad A. Vasef, MD, is a Professor at the Department of Pathology and Director of MGP Fellowship Program at The University of New Mexico Health Sciences Center. He is also Medical Director of Molecular Diagnostics, and works for TriCore Reference Laboratories in Albuquerque, New Mexico.

Inhalt

Part I: Introduction

Hematopoiesis and Bone Marrow Histology

Bone Marrow Examination and Techniques

Bone Marrow Reporting

Overview of Constitutional and Acquired Bone Marrow Disorders

Part II: Anemia

Overview of Anemia

SECTION 1: ACQUIRED ANEMIAS

Iron Deficiency Anemia

Autoimmune Hemolytic Anemias

Alloimmune Hemolytic Anemia and Hemolytic Disease of Newborn

Microangiopathic Hemolytic Anemia

Megaloblastic Anemia

Acquired Nonneoplastic Sideroblastic Anemia

Alcoholism-Associated Anemia

Anemia in the Elderly

Copper Deficiency-Associated Anemia

Acquired Red Cell Aplasia

Transient Erythroblastopenia of Childhood

Parvovirus-Induced Red Cell Aplasia

Paroxysmal Nocturnal Hemoglobinuria

Acquired Aplastic Anemia

SECTION 2: CONSTITUTIONAL ANEMIAS

Thalassemia

Sickle Cell Anemia

Pyruvate Kinase Deficiency

Hereditary Spherocytosis

Hereditary Elliptocytosis, Including Hereditary Pyropoikilocytosis

Diamond-Blackfan Anemia

Fanconi Anemia

Congenital Dyserythropoietic Anemia

Congenital Sideroblastic Anemia

Congenital Megaloblastic Anemia

Part III: Erythrocytosis

SECTION 1: CONSTITUTIONAL

Congenital Erythrocytosis

SECTION 2: ACQUIRED

Acquired Erythrocytosis

Part IV: Benign Leukocyte Disorders in Blood and Bone Marrow

Overview of Benign Leukocyte Disorders in Blood and Bone Marrow

Pancytopenia

Neutropenia

Neutrophilia

Monocytosis

Eosinophilia

Basophilia

Lymphocytosis

Lymphopenia, Constitutional and Acquired

Plasmacytosis of Bone Marrow

Hematogones in Bone Marrow

Lymphoid Aggregates in Bone Marrow

Granulomas in Bone Marrow

Part V: Constitutional Granulocytic Disorders

SECTION 1: CONSTITUTIONAL NEUTROPENIAS

Severe Congenital Neutropenia and Cyclic Neutropenia

Shwachman-Diamond Syndrome

Chediak-Higashi Syndrome

Myelokathexis in WHIM Syndrome

SECTION 2: CONSTITUTIONAL NEUTROPHIL ANOMALIES

Pelger-Huet Anomaly

MYH9-Related Disorders

Selected Lysosomal Storage Diseases With Abnormal Leukocyte Granulation

Part VI: Megakaryocytic Disorders

Overview of Megakaryocytic Disorders

SECTION 1: ACQUIRED PLATELET DISORDERS WITH THROMBOCYTOPENIA

Immune-Mediated Thrombocytopenia

Hemolytic-Uremic Syndrome

Thrombotic Thrombocytopenic Purpura

Pregnancy-Associated Thrombocytopenia

SECTION 2: CONSTITUTIONAL PLATELET DISORDERS WITH THROMBOCYTOPENIA

Thrombocytopenia Absent Radius Syndrome

Congenital Amegakaryocytic Thrombocytopenia

Gray Platelet Syndrome

Wiskott-Aldrich Syndrome-Related Disorders

Congenital Thrombotic Thrombocytopenic Purpura

SECTION 3: THROMBOCYTOSIS

Thrombocytosis

Part VII: Infection

Overview of Infection

Hantavirus Pulmonary Syndrome

Human Immunodeficiency Virus

Infectious Mononucleosis Syndromes (Epstein-Barr Virus, Cytomegalovirus)

Parvovirus B19 Infection

Bacterial Infections, Blood and Bone Marrow Features

Fungal Infections, Blood and Bone Marrow Features

Helminthic Infections

Malaria

Other Protozoan Infections

Part VIII: Miscellaneous Nonneoplastic Disorders and Conditions

Overview and Classification of Hemophagocytic Disorders in Bone Marrow

Hematologic Manifestations of Collagen Vascular Disorders

Hematologic Manifestations of Chronic Renal Disorders

Lysosomal Storage Diseases With Predominantly Histiocytic Storage

Other Pregnancy-Associated Hematologic Disorders

Gelatinous Transformation and Other Bone Marrow Stromal Disorders

Crystals in Bone Marrow

Bone Abnormalities in Bone Marrow Specimens

Part IX: Myeloid Neoplasms

Overview and Classification of Myeloid Neoplasms

Protocol for the Examination of Specimens From Patients With Hematopoietic Neoplasms Involving Bone Marrow

Clinical Practice Guidelines for Initial Work-Up of Acute Leukemia

SECTION 1: MYELOPROLIFERATIVE NEOPLASMS

Overview of Myeloproliferative Neoplasms

Chronic Myelogenous Leukemia, BCR/ABL1+

Chronic Neutrophilic Leukemia

Polycythemia Vera

Primary Myelofibrosis

Essential Thrombocythemia

Chronic Eosinophilic Leukemia, Not Otherwise Specified

Systemic Mastocytosis

Mast Cell Leukemia

Myeloproliferative Neoplasm, Unclassifiable

SECTION 2: MYELOID AND LYMPHOID NEOPLASMS WITH EOSINOPHILIA AND ABNORMALITIES OF PDGFRA, PDGFRB, AND FGFR1

Myeloid and Lymphoid Neoplasms With PDGFRA Rearrangement

Myeloid Neoplasms With PDGRFB Rearrangments

Myeloid and Lymphoid Neoplasms With FGFR1 Abnormalities

SECTION 3: MYELODYSPLASTIC & MYELOPROLIFERATIVE NEOPLASMS

Overview of Myelodysplastic/Myeloproliferative Neoplasms

Chronic Myelomonocytic Leukemia

Atypical Chronic Myeloid Leukemia, BCR/ABL1-

Juvenile Myelomonocytic Leukemia

RARS-T

Myelodysplastic/Myeloproliferative Neoplasms, Unclassifiable

SECTION 4: MYELODYSPLASTIC SYNDROMES

Overview and Classification of Myelodysplastic Syndromes

Myelodysplasia With Single Lineage Dysplasia

Myelodysplasia With Ring Sideroblasts

Myelodysplasia With Multilineage Dysplasia

Myelodysplasia With Increased Blasts

Myelodysplastic Syndrome With Isolated del(5q)

Myelodysplastic Syndrome, Unclassifiable

Childhood Myelodysplastic Syndrome (Refractory Cytopenia of Childhood)

SECTION 5: ACUTE MYELOID LEUKEMIA

Overview of Acute Myeloid Leukemia

Familial AML/MDS

Acute Myeloid Leukemia With t(8;21)(q22;q22), RUNX1-RUNX1T1

Acute Myeloid Leukemia With inv(16)(p13.1q22) or t(16;16)(p13.1;q22), CBFB-MYH11

Acute Promyelocytic Leukemia With t(15;17)(q22;q21), PML-RARA

Acute Promyelocytic Leukemia With Variant RARA Rearrangement

Acute Myeloid Leukemia With t(9;11)(p22;q23), MLLT3-MLL

Additional Genetic Subtypes of Acute Myeloid Leukemia, Including t(6;9), inv(3), t(1;22), Mutated NPM1, Mutated CEBPA

Acute Myeloid Leukemia With Myelodysplasia- Related Changes

Therapy-Related Myeloid Neoplasms

Acute Myeloid Leukemia With Minimal Differentiation

Acute Myeloid Leukemia Without Maturation

Acute Myeloid Leukemia With Maturation

Acute Myelomonocytic Leukemia

Acute Monoblastic and Monocytic Leukemia

Acute Erythroid Leukemia

Acute Megakaryoblastic Leukemia

Acute Basophilic Leukemia

Acute Panmyelosis With Myelofibrosis

Myeloid Proliferations Related to Down Syndrome

Blastic Plasmacytoid Dendritic Cell Neoplasm

Part X: Acute Leukemias of Ambiguous Lineage

Acute Undifferentiated Leukemia

Mixed Phenotype Acute Leukemia

Part XI: Lymphoid Neoplasms

Overview of Lymphoid Neoplasms

Protocol for the Examination of Specimens from Patients With Non-Hodgkin Lymphoma/Lymphoid Neoplasms

SECTION 1: B-PRECURSOR NEOPLASMS

B-Lymphoblastic Leukemia

Novel Genetic Subtypes of B-Lymphoblastic Leukemia

SECTION 2: T-PRECURSOR NEOPLASMS

T-Lymphoblastic Leukemia/Lymphoma

ETP-ALL

SECTION 3: MATURE B-CELL NEOPLASMS

Overview and Classification of Mature Leukemias, Immunosecretory Lymphomas

Monoclonal B Lymphocytes

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

B-Cell Prolymphocytic Leukemia

Splenic B-Cell Marginal Zone Lymphoma

Hairy Cell Leukemia

Splenic B-Cell Leukemia, Hairy Cell Leukemia Variant

Lymphoplasmacytic Lymphoma

Gamma Heavy Chain Disease

Monoclonal Gammopathy of Undetermined Significance

Plasma Cell Myeloma

Burkitt Leukemia/Lymphoma

Mantle Cell Lymphoma in Blood and Bone Marrow

Follicular Cell Lymphoma in Blood and Bone Marrow

Marginal Zone Lymphoma in Blood and Bone Marrow

Large Cell Lymphoma in Blood and Bone Marrow

Other B-Cell Non-Hodgkin Lymphomas Involving Blood and Bone Marrow

SECTION 4: MATURE T/NK-CELL NEOPLASMS

Overview and Classification of Mature T/NK-Cell Neoplasms

T-Cell Prolymphocytic Leukemia

T-Cell Large Granular Lymphocytic Leukemia

Chronic Lymphoproliferative Disorder of NK Cells

Aggressive NK-Cell Leukemia

Adult T-Cell Leukemia

Mycosis Fungoides/Sézary Syndrome

Anaplastic Large Cell Lymphoma in Blood and Bone Marrow

Other T-Cell Non-Hodgkin Lymphomas Involving Blood and Bone Marrow

SECTION 5: HODGKIN LYMPHOMA IN BONE MARROW

Hodgkin Lymphoma in Bone Marrow, Classic and Lymphocyte Predominant Subtypes

Protocol for the Examination of Specimens from Patients With Hodgkin Lymphoma

Part XII: Other Neoplasms Involving Bone Marrow

Langerhans Cell Histiocytosis in Bone Marrow

Hemophagocytic Disorders

Posttransplant Lymphoproliferative Disorders in Bone Marrow

Metastatic Carcinoma and Sarcoma

Produkt-Details

• Erscheinungsdatum: 05.04.2017
• Reihe/Serie: Diagnostic Pathology
• Verlagsort: Philadelphia
• Sprache: englisch
• Maße: 216 x 276 mm
• Gewicht: 2900 g
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Hämatologie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Anamnese / Körperliche Untersuchung
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Pathologie
• ISBN-10: 0-323-39254-7 / 0323392547
• ISBN-13: 978-0-323-39254-9 / 9780323392549
• Zustand: Neuware