Sickle Cell Disease
Oxford University Press (Verlag)
978-0-19-261753-8 (ISBN)
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Sickle cell disease is one of the most common inherited blood disorders, affecting large numbers of people in the Americas, Africa, India and the Mediterranean countries. It was the first disease for which the precise genetic abnormality was identified and has served as a prototype in molecular medicine. As a result, the abnormalities of red cell structure and function which it causes have been explored. These advances are described in the first part of the book. This volume also provides an up-to-date review of the clinical management of sickle cell disease - its diagnosis, clinical features and therapy. The author has summarized information from various journal sources, aiming to provide a critical review of the subject.
Preface. Basic concepts; distribution of sickle cell disease; nomenclature and genetics of sickle cell disease; diagnosis of sickle cell disease; pathophysiology of sickle cell disease; historical aspects; the bone marrow; the blood; the liver; the spleen; the immune system; the gut; cardiovascular system; pulmonary system; leg ulceration; bone and joint lesions; the painful crisis; renal manifestations; priapism; the nervous system; the eyes; physical and sexual development; pregnancy and contraception; homozygous sickle cell disease; sickle cell - haemoglobin C disease; sickle cell - beta thalassaemia; other forms of sickle cell disease; sickle cell - hereditary persistence of fetal haemoglobin; the sickle cell trait; age and patterns of clinical involvement; causes of mortality; general supportive measures; blood transfusion; therapeutic attempts to inhibit sickling; surgery and anaesthesia; screening and sickle cell clinics; the epidemiology of sickle cell disease. References. Index.
| Zusatzinfo | illustrations, bibliography, references, index |
|---|---|
| Verlagsort | Oxford |
| Sprache | englisch |
| Maße | 150 x 230 mm |
| Gewicht | 886 g |
| Themenwelt | Medizinische Fachgebiete ► Innere Medizin ► Hämatologie |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin | |
| ISBN-10 | 0-19-261753-2 / 0192617532 |
| ISBN-13 | 978-0-19-261753-8 / 9780192617538 |
| Zustand | Neuware |
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