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G Protein-Coupled Receptor Kinases

Buch | Hardcover
329 Seiten
2016 | 1st ed. 2016
Humana Press Inc. (Verlag)
978-1-4939-3796-7 (ISBN)

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This collection explores up-to-date descriptions of known G protein-coupled receptor kinase (GRK)-dependent mechanisms, both associated with G protein-coupled receptor (GPCR) functions and the receptor-independent. The chapters cover a wide range of studies from invertebrates to humans, with sections of the volume covering GRK structure, mechanisms of activation, and interaction with GPCRs, GRKs in cell signaling, as well as physiological and pathophysiological mechanisms regulated by GRKs.  Written for the Methods in Pharmacology and Toxicology series, this book features the kind of practical detail necessary for success in the laboratory. Authoritative and timely, G Protein-Coupled Receptor Kinases features the kind of comprehensive mechanistic elucidation of GRK functions and their regulation in cells necessary for a better understanding of cell biology as well as for devising novel research approaches and therapeutic strategies.

G Protein-Coupled Receptor Kinases (GRKs) History: Evolution and Discovery.- Structure and Function of G Protein-Coupled Receptor Kinases 1 and 7.- Visual G Protein-Coupled Receptor Kinases.- Molecular Basis for Targeting, Inhibition, and Receptor Phosphorylation in the G Protein-Coupled Receptor Kinase 4 Subfamily.- “Barcode” and Differential Effects of GPCR Phosphorylation by Different GRKs.- Cell-Type Specific GRK2 Interactomes: Physiopathological Implications.- Differential Regulation of IGF-1 and Insulin Signaling by GRKs.- Differential Control of Potassium Channel Activity by GRK2.- Critical Role of GRK2 in the Prevention of Chronic Pain.- Roles of GRK Dysfunction in Alzheimer’s Pathogenesis.- Regulation of Dopamine-Dependent Behaviors by G Protein-Coupled Receptor Kinases.- G Protein-Coupled Receptors and Their Kinases in Cardiac Regulation.- GRK Roles in C. elegans.- Evolutionarily Conserved Role of G Protein-Coupled Receptor Kinases in the Hedgehog Signaling Pathway.

Erscheinungsdatum
Reihe/Serie Methods in Pharmacology and Toxicology
Zusatzinfo 33 Illustrations, color; 3 Illustrations, black and white; XI, 329 p. 36 illus., 33 illus. in color.
Verlagsort Totowa, NJ
Sprache englisch
Maße 178 x 254 mm
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
Medizin / Pharmazie Pharmazie
Studium 2. Studienabschnitt (Klinik) Pharmakologie / Toxikologie
Schlagworte cell signaling • GPCR signaling • G protein-coupled receptors (GPCRs) • GRK phosphorylation • GRKs • Pathophysiological regulation • Therapeutic Strategies
ISBN-10 1-4939-3796-0 / 1493937960
ISBN-13 978-1-4939-3796-7 / 9781493937967
Zustand Neuware
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