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The clinically organ-confined adenocarcinoma of the prostate

Natural history, selection criteria for radical prostatectomy and prognostic factors based on long-term follow-up

Hans-Peter Schmid (Herausgeber)

Buch | Softcover

VIII, 74 Seiten

1994 | 1. Softcover reprint of the original 1st ed. 1994
Steinkopff (Verlag)
978-3-7985-0998-6 (ISBN)

Lese- und Medienproben

Inhaltsverzeichnis (PDF)

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Dr. Hans-Peter Schmid has addressed in this monograph the basic dilemmas surrounding prostate cancer. These dilemmas include the 40 % histologic incidence of invasive cancer in men in comparison to a 3 % death rate, the extraordinary slow doubling time of four to five years for untreated early clinical stages (T1 and T2 cancers), the limited life span of even healthy men over 70 years of age, and the national and international debates of how to treat this cancer. It is important, however, to recognize that despite these uncertainties, prostate cancer is probably the most predictive of all human solid tumors. Dr. Schmid has addressed the basis for much of this predictability in this monograph. The level of serum PSA and its rate of increase in the untreated patient with a prostate size of less than 50 grams is undoub tedly the most useful of all measurements in predicting volume and grade of the cancer, but it is closely followed by assessment of the extent and percent of grade 4 and 5 cancer in six systematic, spatially separated biopsies. Estimating the amount of suspected cancer on digital rectal examination by assigning a clinical stage is useful, but far less quantitative than PSA and systematic biopsies. The Basel series in this monograph adds strong support to these basic concepts. April 1994 ThomasA. Stamey, M. D. Professor and Chairman Department of Urology Stanford University School of Medicine Stanford, California, USA v Contents Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . V I. 1 Introduction and overview . . . . . . . . . . . . . . . . . . . . . . . . . . .

I. Introduction and overview.- 1.1 Historical remarks.- 1.2 Epidemiology.- 1.3 Etiology.- 1.4 Diagnosis.- 1.5 Staging and grading.- 1.6 Treatment options.- II. Natural history.- 2.1 Dilemma of latent prostate cancer.- 2.2 Concept of biologic tumor progression.- 2.3 Tumor volume and Gleason grade.- 2.4 Growth pattern and doubling time.- 2.5 Impact on early diagnosis and management.- III. Selection criteria for radical prostatectomy.- 3.1 Materials and methods.- 3.2 Results.- 3.3 Discussion.- IV. Prognostic factors based on long-term follow-up.- 4.1 Tumor volume.- 4.2 Conventional morphology.- 4.3 Immunohistochemistry.- V. References.- VI. Summary.- VII. Acknowledgments.

Erscheint lt. Verlag	31.8.1994
Reihe/Serie	Fortschritte der Urologie und Nephrologie
Zusatzinfo	VIII, 74 p.
Verlagsort	Heidelberg
Sprache	englisch
Maße	170 x 244 mm
Gewicht	161 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Urologie
Schlagworte	Cancer • carcinoma • Grading • Prostate Cancer • Prostatectomy • Staging • Tumor • tumor progression
ISBN-10	3-7985-0998-0 / 3798509980
ISBN-13	978-3-7985-0998-6 / 9783798509986
Zustand	Neuware