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Clinical Pharmacology in the Elderly

Reference Ranges and Biological Variations After Repeated Measurements

Hans-Peter Breuel (Autor)

Buch | Softcover

VIII, 182 Seiten

1995 | 1. Softcover reprint of the original 1st ed. 1996
Springer Berlin (Verlag)
978-3-540-59495-6 (ISBN)

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The appropriate and rational use of drugs by the elderly is a matter of growing medical and social concern. Persons aged 65 years and older constitute about 12%-15% of the population in the Western world, and the total number of the elderly will increase significantly in the coming years. This population accounts for 30% of all the prescription drugs used. Aging, specifically the transition from middle to old age, is a complex process. From the perspective of clinical pharmacology, these pathophysiological changes may reasonably be expected to alter responsiveness to drugs. The age-related differences in response to drugs can arise from alterations in pharmacokinetics or pharmacodynamics. This makes it mandatory that clinical pharma cological studies be carried out in the elderly during extended phase I studies. The older the population likely to use the drug, the more important it is to include the very old. It is also important not to exclude .... :''lecessarily patients with concomitant illnesses; it is only by observing, such patients that drug-disease interactions can be detected. Reports from surveillance systems have greatly increased our awareness of problems associated with drug therapy in old age.

1 Introduction.- 2 Theories of Aging.- 3 Changes in Body Functions, Pharmacokinetics, and Receptor Sensitivity with Age.- 3.1 Changes in Central Nervous System.- 3.2 Cardiovascular and Pulmonary Changes.- 3.3 Changes in Clinical Chemistry and Hematology.- 3.4 Changes in Pharmacokinetics.- 3.5 Changes in Receptor Sensitivity.- 4 Practical Aspects in Performing Clinical Trials in Elderly Subjects.- 4.1 Recruitment of Subjects.- 4.2 Performance of the Study.- 4.3 Safety Aspects.- 4.4 Sample Size.- 4.5 Compliance of Subjects with Medication and Study Regulations.- 5 Experimental Findings in Elderly Subjects.- 5.1 Method.- 5.2 Experimental Data.- 5.3 Consequences from Experimental Data in Healthy Subjects.- 6 Statistical Details.- 6.1 Blood Pressure.- 6.2 Ambulatory Blood Pressure Monitoring.- 6.3 ECG Times.- 6.4 Ambulatory ECG Monitoring.- 6.5 Spirometry (FEV1).- 6.6 Clinical Chemistry.- 6.7 Hematology.- References.

Erscheint lt. Verlag	1.12.1995
Mitarbeit	Assistent: P.R. Heine, J. Horkulak, G. Weyer
Vorwort	J. Kuhlmann
Zusatzinfo	VIII, 182 p. 2 illus.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	400 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Geriatrie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pharmazie
Schlagworte	Absorption • Chemistry • clinical trial • elderly patients • electrocardiogram (ECG) • Kinetics • Metabolism • Pharmacokinetics • pharmacology
ISBN-10	3-540-59495-7 / 3540594957
ISBN-13	978-3-540-59495-6 / 9783540594956
Zustand	Neuware