The Interface Between Innate and Acquired Immunity

Buch | Hardcover

XIII, 118 Seiten

2002 | 2002
Springer Berlin (Verlag)
978-3-540-42894-7 (ISBN)

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All multicellular organisms may possess innate immunity mediated by defense mechanisms with which the organism is born. In recent years much has been learned about the diversity of innate immune mechanisms. A large array of naturally produced antimicrobial peptides has been de fined. A variety of cell surface receptors that recognize common patterns displayed by infectious organisms have been identified along with the intracellular pathways that these receptors use to activate cellular defense functions. Cell surface receptors on natural killer (NK) cells have been shown to sense microbial invasion in neighboring cells, thereby setting into motion their elimination by cy totoxic mechanisms. Other receptors have been found to facilitate phagocytosis and intracellular killing of microbes by phagocytic cells. These and other natural defense mechanisms have traditionally been viewed as the first line of body defense in vertebrate species that also possess the capacity for acquired or adaptive immunity. Sharks and all of the other jawed vertebrates generate large repertoires of T and B lymphocyte clones that display different antigen specific receptors in the form ofT cell receptors (TCR) and immunoglobulins (Ig) that allow them to recognize and respond to antigens in collaboration with antigen-present ing cells. Memory T and B cells are then generated to allow faster and heightened cellular and humoral immune re sponses on secondary antigen encounter. In recent years it has also become obvious that innate immune responses can directly influence adaptive immune responses in ways that will enhance body defense.

List of Contents.- The Relationship of Inflammation and Initiation of Autoimmune Disease: Role of TNF Super Family Members.- Surface Receptors that Regulate the NK Cell Function: Beyond the NK Cell Scope.- Checkpoints in the Regulation of T Helper 1 Responses.- The Role of Complement in Innate and Adaptive Immunity.- Several MHC-Linked Ig Superfamily Genes Have Features of Ancestral Antigen-Specific Receptor Genes.- Coat Protein Transgenic Papaya: "Acquired" Immunity for Controlling Papaya Ringspot Virus.- Fc Receptor Homologs (FcRH1-5) Extend the Fc Receptor Family.

Erscheint lt. Verlag	26.3.2002
Reihe/Serie	Current Topics in Microbiology and Immunology
Zusatzinfo	XIII, 118 p.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	402 g
Themenwelt	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
Themenwelt	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
Schlagworte	Antigen • antigen-specific receptor genes • autoimmune disease • genes • Histocompatibility • Immunität • immunity • necrosis • NK cells • Phylogeny • Protein • T Cell • T helper cells • Virus
ISBN-10	3-540-42894-1 / 3540428941
ISBN-13	978-3-540-42894-7 / 9783540428947
Zustand	Neuware