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Pharmacokinetic Challenges in Drug Discovery

O. Pelkonen, A. Baumann, A. Reichel (Herausgeber)

Buch | Hardcover

XIV, 301 Seiten

2002
Springer Berlin (Verlag)
978-3-540-42585-4 (ISBN)

Lese- und Medienproben

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Despite increased spending on research and development, the number of new medicines marketed successfully continues to decline. The pharmaceutical industry is therefore focussing on ways to reduce attrition by addressing frequent reasons for clinical drug failures very early in the drug discovery process. One of the biggest challenges is the pharmacokinetic (PK) optimization of drug candidates tailored and predicted to have appropriate absorption, distribution, metabolism and excretion (ADME) characteristics in humans. This book describes how traditional pharmacokinetic approaches and methods are being re-invented to meet specific needs dictated by the dynamics of the drug discovery process. The book gives an overview of state-of-the-art tools, and their use in the decision-making process is discussed by a number of scientists from leading pharmaceutical companies.

Zusatzinfo	83 figs., 18 tabs.
Sprache	englisch
Gewicht	540 g
Einbandart	gebunden
Themenwelt	Medizin / Pharmazie ► Pharmazie
Schlagworte	HC/Medizin/Pharmazie
ISBN-10	3-540-42585-3 / 3540425853
ISBN-13	978-3-540-42585-4 / 9783540425854
Zustand	Neuware