Dextromethorphan

Pharmacology, Clinical Uses & Health Effects

Buch | Hardcover

216 Seiten

2016
Nova Science Publishers Inc (Verlag)
978-1-63484-016-3 (ISBN)

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Dextromethorphan (DM) is an over-the-counter antitussive drug that is also used as one of the active ingredients in many cold and cough medicines. In recent years, DM has also been used in other medicines, ranging from pain relief (as either the primary analgesic or an opioid potentiater) over psychological applications to the treatment of addiction. Pharmacodynamics of DM have been gradually discovered with the elucidation of the following properties, including uncompetitive NMDA receptor antagonist, 1 and 2 sigma receptor agonists, 3 4-nACh receptor antagonist, and others. DM is transformed to its primary and active metabolite dextrorphan predominantly via the metabolic enzyme cytochrome P450 (CYP) 2D6. Hence, DM is the first-choice substrate for CYP2D6 phenotyping because it is relatively safe and possesses many favorable pharmacokinetic characteristics for a marker substrate. This book aims to meet the needs of basic molecular biochemists, pharmacologists, pharmacists, medical students, clinical practitioners and scientists, as well as broad readers who wish to understand the pharmacology of DM and its clinical uses. The contributing authors are basic scientists, pharmacologists, pharmacists and on-service physicians in neuro-psychiatric, anesthesiologic and hepatologic fields from the Czech Republic, Austria, the United States, and China. As a collection of masterpieces by well-known experts, this book presents current research in the study of DM, focusing on its pharmacology, clinical uses and health effects. Topics discussed in this compilation include the new pharmacological application of DM; pharmacogenetics of DM; pharmacodynamics and toxicological profiles of DM; long cutaneous block by lidocaine and DM; toxic and beneficial effects of DM on the central nervous system; pharmacokinetics of DM and drug interactions; DM as a probe drug for CYP2D6 and CYP3A4 phynotyping; evaluation of CYP2D6 in DM-herb interactions; and clinical uses and health effects of DM.

Dr Xin Wang received his Ph.D. degree in pharmacology from the Chinese University of Hong Kong, and postdoctoral training in the University of Texas Medical Branch. He has been working in the East China Normal University as associate professor since 2011. His research fields include pharmacokinetics, integrative approach for the study of anticancer effects of Chinese medicinal (CM) herbs (chemical analysis, pharmacology, pharmacokinetics, adverse effect/toxicity, and quality control of CM herbs), and herb-drug interactions, in particular chemopreventive and synergistic anticancer effects of CM herbs in the combinational chemotherapy of anticancer drugs. Currently, Dr. Wang is hosting or participating in many projects supported by the Science and Technology Commission of Shanghai Municipality and the National Natural Science Foundation of China. Dr. Wang has published more than 30 SCI papers in international peer-reviewed journals and contributed four book chapters. Meanwhile, he is dedicated to social activities and serves as the editorial board member and ad-hoc reviewer of many SCI journals, such as Gene, Journal of Translational Medicine, Toxicology Research, Phytomedicine, Journal of Pharmaceutical and Biomedical Analysis, Journal of Pharmacy and Pharmacology, Phytotherapy Research, Biomedical Chromatography, European Journal of Histochemistry, and Fitoterapia et al.

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Erscheinungsdatum	08.01.2016
Verlagsort	New York
Sprache	englisch
Maße	180 x 260 mm
Gewicht	538 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
ISBN-10	1-63484-016-X / 163484016X
ISBN-13	978-1-63484-016-3 / 9781634840163
Zustand	Neuware