Vaccine Adjuvants

Charles J. Hackett, Donald A. Harn Jr (Herausgeber)

Buch | Hardcover

284 Seiten

2005
Humana Press Inc. (Verlag)
978-0-89603-892-9 (ISBN)

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A cutting-edge review of the major research areas of adjuvant discovery, design, development, and use. The authors lay down a rational basis for vaccine adjuvant function and analyze a number of significantly distinct adjuvant-active molecules to illuminate the principles of their function and use. The focus is on specific receptor-ligand interactions, including the molecular features needed for a compound to possess adjuvant activity. The critical interface zone between the innate and adaptive immune systems is also analyzed to show how adjuvants exert their effects on T- and B-cell activation. Additional chapters address the possibility of tailoring adjuvants to yield optimally safe and effective responses.

Microbial Pathogenesis and the Discovery of Toll-Like Receptor Function.- Dendritic Cells.- Achieving Transcriptional Specificity in NF-?B-Dependent Inflammatory Gene Expression.- Adjuvants and the Initiation of T-Cell Responses.- Mechanism for Recognition of CpG DNA.- CpG ODN As a Th1 Immune Enhancer for Prophylactic and Therapeutic Vaccines.- Modified Bacterial Toxins.- Glycosylphosphatidylinositol Anchors As Natural Immunological Adjuvants Derived From Protozoan Parasites.- The Immunomodulatory Glycan LNFPIII/Lewis X Functions As a Potent Adjuvant for Protein Antigens.- Immune and Antiviral Effects of the Synthetic Immunomodulator Murabutide.- Effects of QS-21 on Innate and Adaptive Immune Responses.- Monophosphoryl Lipid A and Synthetic Lipid A Mimetics As TLR4-Based Adjuvants and Immunomodulators.- Microparticles and DNA Vaccines.

Reihe/Serie	Infectious Disease
Zusatzinfo	28 Illustrations, black and white; XII, 284 p. 28 illus.
Verlagsort	Totowa, NJ
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
Themenwelt	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
ISBN-10	0-89603-892-0 / 0896038920
ISBN-13	978-0-89603-892-9 / 9780896038929
Zustand	Neuware