The Hsp60 Chaperonin
Springer International Publishing (Verlag)
978-3-319-26086-0 (ISBN)
Introduction.- Historical sketch of the discovery and recognition of the function of chaperonins.- Molecular structure of chaperonins.- Folding by enclosure in the chaperonin cavity.- Evolutionary origins and family relations.- Chaperoning mechanisms: folding helpers, folding protectors or misfolding blockers?.- Sequence variations in proteins affecting chaperonin dependence.- Genetic organization of type I chaperonin genes.- Regulation of type I chaperonin gene expression.- Subcellular localization.- Posttranslational modifications.- Variations in Hsp60 and Hsp10 in humans.- Type I chaperonins are essential for cell viability and mutations cause deficiency phenotypes.- Human diseases caused by genetic mutations in the Hsp60/Hsp10 system.- Molecular investigations of disease mechanisms.- Molecular investigations of disease mechanisms.- Outlook.
Erscheinungsdatum | 08.10.2016 |
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Reihe/Serie | Protein Folding and Structure | SpringerBriefs in Molecular Science |
Zusatzinfo | XV, 85 p. 19 illus., 4 illus. in color. |
Verlagsort | Cham |
Sprache | englisch |
Maße | 155 x 235 mm |
Themenwelt | Medizin / Pharmazie |
Naturwissenschaften ► Biologie ► Allgemeines / Lexika | |
Naturwissenschaften ► Biologie ► Biochemie | |
Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie | |
Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie | |
Naturwissenschaften ► Chemie ► Organische Chemie | |
Schlagworte | Biomedical and Life Sciences • bioorganic chemistry • Chaperonin • Hsp60 • Hsp60 Function in Mitochondria • Molecular Chaperone • Molecular Medicine • Neurodegeneration • Protein assembly • Protein Folding • Protein quality control • Protein Science |
ISBN-10 | 3-319-26086-3 / 3319260863 |
ISBN-13 | 978-3-319-26086-0 / 9783319260860 |
Zustand | Neuware |
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