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Cancer Drug Resistance

Overviews and Methods
Buch | Hardcover
314 Seiten
2016 | 1st ed. 2016
Humana Press Inc. (Verlag)
978-1-4939-3345-7 (ISBN)

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This volume discusses the latest advancements and technologies used in cancer drug resistance research. Cancer Drug Resistance: Overviews and Methods contains chapters that cover topics such as: studying the mechanics of resistance to DNA damaging therapeutic drugs; studies to delineate the role of efflux transporters; expression of drug transporters; resistance to targeted therapies in breast cancer; the role of microRNAs in current pancreatic cancer treatment; and cancer exosomes as mediators of drug resistance or clinical and molecular methods in drug development and the use of bioinformatics in the management of cancer drug resistance data. Written in the highly successful Methods in Molecular Biology series format, chapters include overviews of the main issues in cancer drug resistance and the respective mechanisms, as well as introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, Cancer Drug Resistance: Overviews and Methods, is a valuable resource to researchers, oncobiologists and clinical oncologists or anyone else who is interested in the study of cancer and its drug resistances.

Cancer Drug Resistance: A Brief Overview from a Genetic Viewpoint.- Classical and Targeted Anti-Cancer Drugs: An Appraisal of Mechanisms of Multidrug Resistance.- In Vitro Methods for Studying the Mechanisms of Resistance to DNA Damaging Therapeutic Drugs.- In Vitro Approaches to Study Regulation of Hepatic Cytochrome P450 (CYP) 3A Expression by Paclitaxel and Rifampicin.- Uptake and Permeability Studies to Delineate the Role of Efflux Transporters.- Dynamics of Expression of Drug Transporters: Methods for Appraisal.- Fluorimetric Methods for Analysis of Permeability, Drug Transport Kinetics, and Inhibition of the ABCB1 Membrane Transporter.- Resistance to Targeted Therapies in Breast Cancer.- MicroRNAs and Cancer Drug Resistance.- The Role of MicroRNAs in Resistance to Current Pancreatic Cancer Treatment: Translational Studies and Basic Protocols for Extraction and PCR Analysis.- Methods for Studying MicroRNAs Expression and Their Targets in Formalin-Fixed, Paraffin-Embedded (FFPE) Breast Cancer Tissues.- The Regulatory Role of Long Non-Coding RNAs in Cancer Drug Resistance.- Cancer Exosomes as Mediators of Drug Resistance.- Isolation and Characterization of Cancer Stem Cells from Primary Head and Neck Squamous Cell Carcinoma Tumors.- Clinical and Molecular Methods in Drug Development: Neoadjuvant Systemic Therapy in Breast Cancer as a Model.- Proteo

mics in the Assessment of the Therapeutic Response of Anti-Neoplastic Drugs: Strategies and Practical Applications.- Managing Drug Resistance in Cancer: Role of Cancer Informatics.

Erscheinungsdatum
Reihe/Serie Methods in Molecular Biology ; 1395
Zusatzinfo 37 Illustrations, color; 10 Illustrations, black and white; XIII, 314 p. 47 illus., 37 illus. in color.
Verlagsort Totowa, NJ
Sprache englisch
Maße 178 x 254 mm
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Onkologie
Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
Medizin / Pharmazie Pharmazie
Medizin / Pharmazie Studium
Schlagworte adenosine5'-triphosphate (ATP) • binding cassette (ABC) transporters • cellular resistance • Chemotherapy • DNA • MicroRNAs • multi-drug resistance (MDR) • Proteomics
ISBN-10 1-4939-3345-0 / 1493933450
ISBN-13 978-1-4939-3345-7 / 9781493933457
Zustand Neuware
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