The Centromere

K. H. Andy Choo (Autor)

Buch | Softcover

318 Seiten

1997
Oxford University Press (Verlag)
978-0-19-857780-5 (ISBN)

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The centromere is an essential structure on all eukaryotic chromosomes that allows the equipartition of chromosomes during mitotic and meiotic cell divisions. This text brings together all available information on the centromere.

The centromere is an essential structure on all eukaryotic chromosomes that allows the equipartition of chromosomes during mitotic and meiotic cell divisions. Since its cytogenetic recognition as a constructed part of a chromosome many decades ago, great advance has been made on our understanding of this intriguing structure, especially at the molecular level. This book brings together all available information on the centromere. It covers in details the DNA and
protein components of this structure, and their individual functions, in species as diverse as budding and fission yeasts, nematodes, Drosophila, mice, and humans; newly discovered roles of the centromere in marshalling "passenger" proteins; important emerging concepts such as latest centromeres and
epigenetic factors; cytogenetic problems associated with centromere abnormalities; and practical application of centromere studies, such as in the construction of human artificial chromosomes for gene therapy. Supported by ample illustration, the book is written with sufficient simplicity and detail to suit both specialist and non-specialist scholars. It is the first book on the subject

1. Introduction ; 2. Centromere of budding yeast S. cerevisiae ; 3. Centromere of fission yeast S. pombe ; 4. Structural Organization and general properties of the higher eukaryotic centromere ; 5. Centromere DNA of higher eukaryotes ; 6. Centromere proteins of higher eukaryotes ; 7. Anomalies of the human centromere ; 8. Practical applications

Erscheint lt. Verlag	1.7.1997
Zusatzinfo	line figures, tables
Verlagsort	Oxford
Sprache	englisch
Maße	157 x 235 mm
Gewicht	499 g
Themenwelt	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
	Naturwissenschaften ► Biologie ► Zellbiologie
ISBN-10	0-19-857780-X / 019857780X
ISBN-13	978-0-19-857780-5 / 9780198577805
Zustand	Neuware