Eicosanoids, Inflammation & Chronic Inflammatory Diseases

Pathophysiology, Health Effects & Targets for Therapies

Buch | Hardcover

272 Seiten

2015
Nova Science Publishers Inc (Verlag)
978-1-63482-799-7 (ISBN)

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Eicosanoids constitute a large and expanding family of bioactive lipids synthesized from polyunsaturated fatty acids (PUFA) to either pro-inflammatory omega-6 arachidonic acid (AA) or anti-inflammatory omega-3 eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). In these last cases, two essential fatty acids (FAs) ( -6 linoleic acid (C18:2n6) and -3 linolenic acid (LA) (C18:3n3) are utilized as substrates and a series of desaturase and elongase enzymes are essential for their production. Among these different members, the AA-derived eicosanoids operate as potent signaling mediators that provide an efficient way for cells to respond to various stimuli. As a result, they act as part of a complex regulatory network and control a number of important physiological processes. Some of these processes include: smooth muscle tone; vascular permeability; platelet aggregation; broncho-constriction/dilation; intestine motility.

Carmela Rita Balistreri received is PhD in Pathobiology in 2007. She is actually an Assistant Professor of Clinical Pathology and a member of the Department of Pathobiology and Medical Biotechnologies, University of Palermo, Italy. In the first phases of her studies, Dr Balistreri has been actively involved in the study on the immunological mechanisms of senescence. After this stage, her main field of scientific interest has been the study of the association between the haemochromatosis gene mutations and longevity and age related diseases. Subsequently, her principal interest has been focused on biogerontological studies, case control studies having the key aim to analyze the role of candidate immune inflammatory genes in longevity and age related diseases. Recently, Dr Balistreri is also focusing her studies on identifying the cellular, molecular and genetic mechanisms involved in the pathophysiology of thoracic aorta aneurysms and mitral valve diseases. Her h-index for the 83 papers (1998 2014) is 23, (http://www.scopus.com). To improve her scientific cultural level and to compare her data with those of other groups, she has attended 78 congresses focused on following topics: Age-related diseases, Immunosenescence, Longevity, Model system, Aging & Wellness and Regenerative Medicine, Cardiovascular diseases. Dr Balistreri received several awards and honors.

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Erscheint lt. Verlag	1.9.2015
Verlagsort	New York
Sprache	englisch
Maße	180 x 260 mm
Gewicht	618 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete
	Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
	Naturwissenschaften ► Biologie ► Biochemie
ISBN-10	1-63482-799-6 / 1634827996
ISBN-13	978-1-63482-799-7 / 9781634827997
Zustand	Neuware