Protein Structure, Stability, and Folding

Buch | Hardcover

252 Seiten

2001
Humana Press Inc. (Verlag)
978-0-89603-682-6 (ISBN)

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In Protein Structure, Stability, and Folding, Kenneth P. Murphy and a panel of internationally recognized investigators describe some of the newest experimental and theoretical methods for investigating these critical events and processes. Among the techniques discussed are the many methods for calculating many of protein stability and dynamics from knowledge of the structure, and for performing molecular dynamics simulations of protein unfolding. New experimental approaches presented include the use of co-solvents, novel applications of hydrogen exchange techniques, temperature-jump methods for looking at folding events, and new strategies for mutagenesis experiments. Unique in its powerful combination of theory and practice, Protein Structure, Stability, and Folding offers protein and biophysical chemists the means to gain a more comprehensive understanding of some of this complex area by detailing many of the major techniques in use today.

Stabilization of Protein Structure.- Protein Stabilization by Naturally Occurring Osmolytes.- TheThermodynamic Linkage Between Protein Structure, Stability, and Function.- Measuring the Conformational Stability of a Protein by Hydrogen Exchange.- Modeling the Native State Ensemble.- Conformational Entropy in Protein Folding.- Turn Scanning.- Laser Temperature-Jump Methods for Studying Folding Dynamics.- Kinetics of Conformational Fluctuations by EX1 Hydrogen Exchange in Native Proteins.- Molecular Dynamics Simulations of Protein Unfolding/Folding.

Erscheint lt. Verlag	1.4.2001
Reihe/Serie	Methods in Molecular Biology ; 168
Zusatzinfo	IX, 252 p.
Verlagsort	Totowa, NJ
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Gesundheitsfachberufe ► Diätassistenz / Ernährungsberatung
Themenwelt	Naturwissenschaften ► Biologie ► Biochemie
ISBN-10	0-89603-682-0 / 0896036820
ISBN-13	978-0-89603-682-6 / 9780896036826
Zustand	Neuware