Hepatitis C Virus: From Molecular Virology to Antiviral Therapy

Buch | Softcover

VIII, 346 Seiten

2015 | 2013
Springer Berlin (Verlag)
978-3-642-42936-1 (ISBN)

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Hepatitis C virus (HCV), a major causative agent of chronic liver disease, is spread throughout the world and around 170 million people are persistently infected. In this volume, world-leading experts in the field of HCV research have compiled the most recent scientific advances to provide a comprehensive and very timely overview of the various facets of HCV. The book starts with a discussion of the possible origin of HCV and its spread among the human population. The focus of the subsequent chapters is on available cell culture and in vivo models before shifting to the molecular and cellular principles underlying the viral replication cycle. These chapters are complemented by insightful descriptions of the innate and adaptive immune responses to HCV as well as the virus-associated pathogenesis. Finally, the development of antiviral therapies, which is closely linked with progress in basic research, and the implementation of those therapies into present and future daily clinical practice are highlighted.

The Origin of Hepatitis C Virus.- Cell Culture Systems for Hepatitis C Virus.- Animal Models for Hepatitis C.- Hepatitis C Virus Entry.- Hepatitis C Virus Proteins: From Structure to Function.- Hepatitis C Virus RNA Translation.- Hepatitis C Virus RNA Replication.- Virion Assembly and Release.- Innate Immune Responses to Hepatitis C Virus.- Adaptive Immune Responses in Hepatitis C Virus Infection.- Liver Injury and Disease Pathogenesis in Chronic Hepatitis C.- Hepatitis C Virus-Specific Directly Acting Antiviral Drugs.- Treatment of Chronic Hepatitis C: Current and Future.

Erscheint lt. Verlag	9.4.2015
Reihe/Serie	Current Topics in Microbiology and Immunology
Zusatzinfo	VIII, 346 p. 34 illus., 20 illus. in color.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
Themenwelt	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
Schlagworte	antibacterial drug resistance • Chronic liver disease • Disease pathogenesis • HCV entry • hepatology • immune response • RNA replication • RNA translation
ISBN-10	3-642-42936-X / 364242936X
ISBN-13	978-3-642-42936-1 / 9783642429361
Zustand	Neuware