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The Practice of Medicinal Chemistry -

The Practice of Medicinal Chemistry

Buch | Hardcover
902 Seiten
2015 | 4th Revised edition
Academic Press Inc (Verlag)
978-0-12-417205-0 (ISBN)
CHF 189,95 inkl. MwSt
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The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery. With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development.
  • Includes updated and expanded material on systems biology, chemogenomics, computer-aided drug design, and other important recent advances in the field
  • Incorporates extensive color figures, case studies, and practical examples to help users gain a further understanding of key concepts
  • Provides high-quality content in a comprehensive manner, including contributions from international chapter authors to illustrate the global nature of medicinal chemistry and drug development research
  • An image bank is available for instructors at www.textbooks.elsevier.com

Camille-Georges Wermuth PhD, Prof. and Founder of Prestwick Chemical, was Professor of Organic Chemistry and Medicinal Chemistry at the Faculty of Pharmacy, Louis Pasteur University, Strasbourg, France from 1969 to 2002. He became interested in Medicinal Chemistry during his two years of military service in the French Navy at the "Centre d'Etudes Physio-biologiques Appliqués la Marine" in Toulon. During this time he worked under the supervision of Dr Henri Laborit, the scientist who invented artificial hibernation and discovered chlorpromazine. Professor Wermuths' main research themes focus on the chemistry and the pharmacology of pyridazine derivatives. The 3-aminopyridazine pharmacophore, in particular, allowed him to accede to an impressive variety of biological activities, including antidepressant and anticonvulsant molecules; inhibitors of enzymes such as mono-amine-oxidases, phosphodiesterases and acetylcholinesterase; ligands for neuro-receptors: GABA-A receptor antagonists, serotonine 5-HT3 receptor antagonists, dopaminergic and muscarinic agonists. More recently, in collaboration with the scientists of the Sanofi Company, he developed potent antagonists of the 41 amino-acid neuropeptide CRF (corticotrophin-releasing factor) which regulates the release of ACTH and thus the synthesis of corticoids in the adrenal glands. Professor Wermuth has also, in collaboration with Professor Jean-Charles Schwartz and Doctor Pierre Sokoloff (INSERM, Paris), developed selective ligands of the newly discovered dopamine D3 receptor. After a three-year exploratory phase, this research has led to nanomolar partial agonists which may prove useful in the treatment of the cocaine-withdrawal syndrome. Dr. Wermuth is co-author or editor of several books, the author of over 250 scientific papers and holds nearly 60 patents. Professor Wermuth is also the recipient of the Charles Mentzer Prize of the Societé Francaise de Chimie Thérapeutique, the L on Velluz Prize of the French Academy of Science, the Prix de l'Ordre des Pharmaciens by the French Academy of Pharmacy and the Nauta Award of the European Federation for Medicinal Chemistry for Pharmacochemistry in 2010.

Section 1 - General Aspects of Medicinal Chemistry Section 2 - Lead Compound Discovery Strategies Section 3 - Primary Exploration of Structure-Activity Relationships Section 4 - Substituents and Functions: Qualitative and Quantitative Aspects of Structure-Activity Relationships Section 5 - Spatial Organization, Receptor Mapping and Molecular Modeling Section 6 - Chemical Modifications Influencing the Pharmacokinetic Properties Section 7 - Pharmaceutical and Chemical Means to Solubility and Formulation Problems

Erscheint lt. Verlag 17.7.2015
Zusatzinfo Approx. 175 illustrations (175 in full color)
Verlagsort San Diego
Sprache englisch
Maße 216 x 276 mm
Gewicht 2699 g
Einbandart gebunden
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
Medizin / Pharmazie Pharmazie
Schlagworte Klinische Pharmazie • Pharmazeutische Chemie • Pharmazeutische Chemie; Handbuch/Lehrbuch
ISBN-10 0-12-417205-9 / 0124172059
ISBN-13 978-0-12-417205-0 / 9780124172050
Zustand Neuware
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