Androgen-Responsive Genes in Prostate Cancer

Regulation, Function and Clinical Applications

Zhou Wang (Herausgeber)

Buch | Softcover

348 Seiten

2015 | 2013 ed.
Springer-Verlag New York Inc.
978-1-4899-8687-0 (ISBN)

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Androgens and androgen receptors (AR) play critical roles in the development and progression of prostate cancer, the most frequently diagnosed cancer and second leading cause of cancer death in US males. AR is an androgen-dependent DNA-binding transcription factor that regulates the expression of androgen-responsive genes. Identification and characterization of androgen-responsive genes provide insights into the cellular mechanisms of androgen action and may lead to new approaches in diagnosis, prognosis, prevention and/or treatment of prostate cancer. This volume provides critical information from well respected experts in the field. Some of the exciting topics include the new understanding of mechanisms underlining the regulation of androgen-responsive gene expression, and functions of various androgen-responsive genes in biological processes essential in carcinogenesis including cell growth, angiogenesis, and epithelial-to-mesenchyme transition (EMT). Other important aspects addressed are the current and potential clinic applications of knowledge on androgen-responsive gene regulation and function. This book is intended for researchers, scientists, faculty, and advanced graduate students with an interest in androgen action and prostate cancer.

The volume editor, Dr. Zhou Wang, is well-noted in the field of prostate cancer and he is theChair for Urological Research at the University of Pittsburgh Medical Center, as well as the co-director of Urological and Prostate Cancer Program at the University of Pittsburgh Cancer Institute.He has also conducted several scientific reviews for several top journals in the area of cancer research.

Preface.- Roles of androgen receptor coregulators and cell signaling in regulation of androgen-responsive genes.- Selective and classical Androgen Response Elements in androgen-regulated gene expression.- Negative androgen-response elements in androgen target genes.- Chromatin looping and long distance regulation by androgen receptor.- The Functionality of Prostate Cancer Predisposition Risk Regions is revealed by AR Enhancers .- Mechanisms of ARE-independent Gene Activation by the Androgen Receptor in Prostate Cancer Cells: potential targets for better intervention strategies.- Androgen action, Wnt signaling, and prostate tumorigenesis.- Toward Revealing the Complexity of Androgen Responsive Protein and Non-coding Transcripts in Prostate Cancer.- Androgen-Responsive Gene Expression in Prostate Cancer Progression.- Androgen receptor regulated genes in prostate cancer initiation vs metastasis.- Androgen-Independent Induction of Androgen-Responsive Genes By Interleukin-6 Regulation.- The effect of AR overexpression on androgen signaling in prostate cancer.- The expression signature of androgen receptor splice variants and their distinctive transcriptional activities in castration-resistant prostate cancer.- Androgen regulation of the cell cycle in prostate cancer.- Androgen Receptor Signaling Interactions Control Epithelial-Mesenchymal Transition (EMT) in Prostate Cancer Progression.- Androgen receptor regulation of serum response factor signaling in prostate cancer.- Regulation of angiogenesis by androgen-responsive gene EAF2.- The role of miR-21, an androgen-regulated microRNA, in prostate cancer.- Androgen dependent oncogenic activation of ETS transcription factors by recurrent gene fusions in prostate cancer: Biological and Clinical Implications.- Clusterin as a target for treatment of castration-resistant prostate cancer.- Index.

Erscheint lt. Verlag	8.2.2015
Zusatzinfo	37 Illustrations, color; 38 Illustrations, black and white; IX, 348 p. 75 illus., 37 illus. in color.
Verlagsort	New York
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Biomedizin
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
Schlagworte	androgen action • androgen receptor coregulators • chromatin looping • miR-21 • prostate tumorigenesis
ISBN-10	1-4899-8687-1 / 1489986871
ISBN-13	978-1-4899-8687-0 / 9781489986870
Zustand	Neuware