Surface Modification of Magnesium and its Alloys for Biomedical Applications (eBook)

Biological Interactions, Mechanical Properties and Testing

Min-Ho Lee, T.S.N. Sankara Narayanan, Il-Song Park (Herausgeber)

eBook Download: PDF | EPUB

2015 | 1. Auflage
380 Seiten
Elsevier Science (Verlag)
978-1-78242-082-8 (ISBN)

Infos

Surface modification of magnesium and its alloys for biomedical applications: Biological interactions, mechanical properties and testing, the first of two volumes, is an essential guide on the use of magnesium as a degradable implant material. Due to their excellent biocompatibility and biodegradability, magnesium based degradable implants provide a viable option for the permanent metallic implants. This volume focuses on the fundamental concepts of surface modification of magnesium, its biological interactions, mechanical properties and, in vitro and in vivo testing. The contents of volume 1 is organized and presented in three parts. Part 1 reviews the fundamental aspects of surface modification of magnesium, including surface design, opportunities, challenges and its role in revolutionizing biodegradable biomaterials. Part 2 addresses the biological and mechanical properties covering an in vivo approach to the bioabsorbable behavior of magnesium alloys, mechanical integrity and, the effects of amino acids and proteins on the performance of surface modified magnesium. Part 3 delves in to testing and characterization, exploring the biocompatibility and effects on fatigue life alongside the primary characteristics of surface modified magnesium. All chapters are written by experts, this two volume series provides systematic and thorough coverage of all major modification technologies and coating types of magnesium and its alloys for biomedical applications. - Expert analysis of the fundamentals in surface modification of magnesium and its alloys for biomedical applications - Includes biological interactions and mechanical properties - Focuses on testing and characterisation, as well as biocompatibility

Inhalt

Front Cover 1
Related titles 3
Surface Modification of Magnesium and its Alloys for Biomedical Applications: Volume 1: Biological Interactions, Mechanical Properties and Testing 4
Copyright 5
Contents 6
List of contributors 10
Woodhead Publishing Series in Biomaterials 12
Part One - Fundamentals of surface-modified magnesium and magnesium alloys for biomedical applications 18
1 - Revolutionising biodegradable biomaterials – significance of magnesium and its alloys 20
1.1 Introduction 20
1.2 Corrosion of magnesium alloys 21
1.3 Ultra-pure magnesium 26
1.4 Measurement of magnesium corrosion 28
1.5 In vitro and in vivo comparison 33
1.6 Magnesium corrosion mechanism 34
1.7 Galvanic corrosion 34
1.8 Summary of important points 34
Acknowledgements 37
References 37
2 - Surface modification of magnesium and its alloys for biomedical applications: opportunities and challenges 46
2.1 Introduction 46
2.2 Thermal, hydrothermal, and alkaline heat treatment-based surface modifications 47
2.3 Chemical surface modifications 52
2.4 Electrochemical surface modification 72
2.5 Plasma surface modification 76
2.6 Laser surface modification 82
2.7 Other methods of surface modification 86
2.8 Summary and concluding remarks 89
References 91
3 - Surface design of biodegradable magnesium alloys for biomedical applications 106
3.1 Introduction 106
3.2 Surface modification techniques 106
3.3 Surface design principles for biodegradable magnesium alloys 115
3.4 Research examples 119
3.5 Summary and future trends 131
Acknowledgements 131
References 131
Part Two - Biological and mechanical properties of surface modified magnesium and magnesium alloys 138
4 - Bioabsorbable behaviour of magnesium alloys – an in vivo approach 140
4.1 Introduction 140
4.2 Requirements with regard to magnesium alloys for in vivo use 141
4.3 Transferability of in vitro findings to in vivo trials: a suitable indicator for in vivo studies? 144
4.4 In vivo biodegradation of magnesium alloys 147
4.5 In vivo biocompatibility of magnesium alloys 157
4.6 Testing of magnesium alloy in or on bone – special considerations 167
4.7 Testing of magnesium alloy in blood vessels – special considerations 176
4.8 Future trends 178
4.9 Further information and advice 180
Acknowledgements 180
References 180
5 - Mechanical integrity of magnesium alloys for biomedical applications 196
5.1 Magnesium and its alloys as implant materials 196
5.2 Corrosion and assisted cracking of magnesium alloys 197
5.3 SCC of magnesium alloys: a biomedical perspective 201
5.4 Phenomenology of SCC of magnesium alloys 202
5.5 Prevention of SCC 215
5.6 Conclusions 216
References 216
6 - Effect of amino acids and proteins on the in vitro performance of coated magnesium for biomedical applications 222
6.1 Introduction 222
6.2 The role of amino acids and proteins in biocorrosion 223
6.3 Effect of amino acids on corrosion performance of magnesium 227
6.4 Effect of proteins on magnesium biocorrosion 231
6.5 Effect of buffer and atmosphere on amino acids/protein-induced corrosion 236
6.6 Conclusions 243
References 245
7 - Biocompatibility of surface-modified magnesium and magnesium alloys 248
7.1 Introduction 248
7.2 Biocompatibility of the materials introduced by surface modification 248
7.3 Biocompatibility of surface-modified magnesium-based metals – in vitro results 253
7.4 Biocompatibility of surface-modified magnesium-based metals – in vivo findings 260
7.5 Influencing factors on the biocompatibility of the surface-modified magnesium-based metals 263
7.6 Future trends 266
7.7 Sources of further information and advice 267
References 268
Part Three - Testing and characterization of surface-modified magnesium and magnesium alloys for biomedical applications 278
8 - Characterization of modified magnesium and magnesium alloys for biomedical applications 280
8.1 Introduction 280
8.2 Characterization methods 283
8.3 Future trends 294
8.4 Sources of additional information and advice 294
References 295
9 - Effect of surface treatments on the fatigue life of magnesium and its alloys for biomedical applications 300
9.1 Introduction 300
9.2 Fatigue behavior of magnesium alloys 301
9.3 Surface treatments 307
9.4 Future trends 320
Acknowledgements 321
References 321
10 - Testing the mechanical properties of surface-modified magnesium and magnesium alloys for biomedical applications 328
10.1 Introduction 328
10.2 Implantation-related mechanical properties 330
10.3 Degradation-related mechanical properties 333
10.4 Effect of surface modifications on implant performance 335
10.5 Testing mechanical properties in vitro 337
10.6 Testing implant performance in vivo 341
10.7 Sources of further information 344
Acknowledgements 345
References 345
11 - Biocompatibility testing and marketing authorisation of degradable magnesium implants 348
11.1 Introduction 348
11.2 Classification – which directive applies? 349
11.3 Testing according to international standards 352
11.4 Biocompatibility – one aspect of biological safety 357
11.5 Preclinical biocompatibility testing of biodegradable magnesium implants for marketing authorisation 363
11.6 Nonstandardised in vitro and in vivo techniques for biocompatibility evaluation of magnesium alloys 367
References 368
Index 372

Textauszug

Woodhead Publishing Series in Biomaterials

1 Sterilisation of tissues using ionising radiations
Edited by J. F. Kennedy, G. O. Phillips and P. A. Williams

2 Surfaces and interfaces for biomaterials
Edited by P. Vadgama

3 Molecular interfacial phenomena of polymers and biopolymers
Edited by C. Chen

4 Biomaterials, artificial organs and tissue engineering
Edited by L. Hench and J. Jones

5 Medical modelling
R. Bibb

6 Artificial cells, cell engineering and therapy
Edited by S. Prakash

7 Biomedical polymers
Edited by M. Jenkins

8 Tissue engineering using ceramics and polymers
Edited by A. R. Boccaccini and J. Gough

9 Bioceramics and their clinical applications
Edited by T. Kokubo

10 Dental biomaterials
Edited by R. V. Curtis and T. F. Watson

11 Joint replacement technology
Edited by P. A. Revell

12 Natural-based polymers for biomedical applications
Edited by R. L. Reiss et al

13 Degradation rate of bioresorbable materials
Edited by F. J. Buchanan

14 Orthopaedic bone cements
Edited by S. Deb

15 Shape memory alloys for biomedical applications
Edited by T. Yoneyama and S. Miyazaki

16 Cellular response to biomaterials
Edited by L. Di Silvio

17 Biomaterials for treating skin loss
Edited by D. P. Orgill and C. Blanco

18 Biomaterials and tissue engineering in urology
Edited by J. Denstedt and A. Atala

19 Materials science for dentistry
B. W. Darvell

20 Bone repair biomaterials
Edited by J. A. Planell, S. M. Best, D. Lacroix and A. Merolli

21 Biomedical composites
Edited by L. Ambrosio

22 Drug–device combination products
Edited by A. Lewis

23 Biomaterials and regenerative medicine in ophthalmology
Edited by T. V. Chirila

24 Regenerative medicine and biomaterials for the repair of connective tissues
Edited by C. Archer and J. Ralphs

25 Metals for biomedical devices
Edited by M. Ninomi

26 Biointegration of medical implant materials: Science and design
Edited by C. P. Sharma

27 Biomaterials and devices for the circulatory system
Edited by T. Gourlay and R. Black

28 Surface modification of biomaterials: Methods analysis and applications
Edited by R. Williams

29 Biomaterials for artificial organs
Edited by M. Lysaght and T. Webster

30 Injectable biomaterials: Science and applications
Edited by B. Vernon

31 Biomedical hydrogels: Biochemistry, manufacture and medical applications
Edited by S. Rimmer

32 Preprosthetic and maxillofacial surgery: Biomaterials, bone grafting and tissue engineering
Edited by J. Ferri and E. Hunziker

33 Bioactive materials in medicine: Design and applications
Edited by X. Zhao, J. M. Courtney and H. Qian

34 Advanced wound repair therapies
Edited by D. Farrar

35 Electrospinning for tissue regeneration
Edited by L. Bosworth and S. Downes

36 Bioactive glasses: Materials, properties and applications
Edited by H. O. Ylänen

37 Coatings for biomedical applications
Edited by M. Driver

38 Progenitor and stem cell technologies and therapies
Edited by A. Atala

39 Biomaterials for spinal surgery
Edited by L. Ambrosio and E. Tanner

40 Minimized cardiopulmonary bypass techniques and technologies
Edited by T. Gourlay and S. Gunaydin

41 Wear of orthopaedic implants and artificial joints
Edited by S. Affatato

42 Biomaterials in plastic surgery: Breast implants
Edited by W. Peters, H. Brandon, K. L. Jerina, C. Wolf and V. L. Young

43 MEMS for biomedical applications
Edited by S. Bhansali and A. Vasudev

44 Durability and reliability of medical polymers
Edited by M. Jenkins and A. Stamboulis

45 Biosensors for medical applications
Edited by S. Higson

46 Sterilisation of biomaterials and medical devices
Edited by S. Lerouge and A. Simmons

47 The hip resurfacing handbook: A practical guide to the use and management of modern hip resurfacings
Edited by K. De Smet, P. Campbell and C. Van Der Straeten

48 Developments in tissue engineered and regenerative medicine products
J. Basu and J. W. Ludlow

49 Nanomedicine: Technologies and applications
Edited by T. J. Webster

50 Biocompatibility and performance of medical devices
Edited by J-P. Boutrand

51 Medical robotics: Minimally invasive surgery
Edited by P. Gomes

52 Implantable sensor systems for medical applications
Edited by A. Inmann and D. Hodgins

53 Non-metallic biomaterials for tooth repair and replacement
Edited by P. Vallittu

54 Joining and assembly of medical materials and devices
Edited by Y. (Norman) Zhou and M. D. Breyen

55 Diamond-based materials for biomedical applications
Edited by R. Narayan

56 Nanomaterials in tissue engineering: Fabrication and applications
Edited by A. K. Gaharwar, S. Sant, M. J. Hancock and S. A. Hacking

57 Biomimetic biomaterials: Structure and applications
Edited by A. J. Ruys

58 Standardisation in cell and tissue engineering: Methods and protocols
Edited by V. Salih

59 Inhaler devices: Fundamentals, design and drug delivery
Edited by P. Prokopovich

60 Bio-tribocorrosion in biomaterials and medical implants
Edited by Y. Yan

61 Microfluidic devices for biomedical applications
Edited by X-J. James Li and Y. Zhou

62 Decontamination in hospitals and healthcare
Edited by J. T. Walker

63 Biomedical imaging: Applications and advances
Edited by P. Morris

64 Characterization of biomaterials
Edited by M. Jaffe, W. Hammond, P. Tolias and T. Arinzeh

65 Biomaterials and medical tribology
Edited by J. Paolo Davim

66 Biomaterials for cancer therapeutics: Diagnosis, prevention and therapy
Edited by K. Park

67 New functional biomaterials for medicine and healthcare
E. P. Ivanova, K. Bazaka and R. J. Crawford

68 Porous silicon for biomedical applications
Edited by H. A. Santos

69 A practical approach to spinal trauma
Edited by H. N. Bajaj and S. Katoch

70 Rapid prototyping of biomaterials: Principles and applications
Edited by R. Narayan

71 Cardiac regeneration and repair Volume 1: Pathology and therapies
Edited by...

Produkt-Details

• Erscheint lt. Verlag: 8.1.2015
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Pflege
• Themenwelt: Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Orthopädie
• Themenwelt: Technik ► Maschinenbau
• Themenwelt: Technik ► Medizintechnik
• ISBN-10: 1-78242-082-7 / 1782420827
• ISBN-13: 978-1-78242-082-8 / 9781782420828