Surface modification of biomaterials can ultimately determine whether a material is accepted or rejected from the human body, and a responsive surface can further make the material "e;smart"e; and "e;intelligent"e;. Switchable and Responsive Surfaces and Materials for Biomedical Applications outlines synthetic and biological materials that are responsive under different stimuli, their surface design and modification techniques, and applicability in regenerative medicine/tissue engineering, drug delivery, medical devices, and biomedical diagnostics. Part one provides a detailed overview of switchable and responsive materials and surfaces, exploring thermo-responsive polymers, environmentally responsive polyelectrolytes and zwitterionic polymers, as well as peptide-based and photonic sensitive switchable materials. Further chapters include a detailed overview of the preparation and analysis of switchable polymer brushes and copolymers for biomedical application. Part two explores the biological interactions and biomedical applications of switchable surfaces, where expert analysis is provided on the interaction of switchable surfaces with proteins and cells. The interaction of stimuli-sensitive polymers for tissue engineering and drug delivery with biosurfaces is critiqued, whilst the editor provides a skillful study into the application of responsive polymers in implantable medical devices and biosensors. - A comprehensive overview of switchable and responsive materials and surfaces- Includes in depth analysis of thermo-responsive polymers, photonic sensitive materials and peptide-based surfaces- Detailed exploration of biological interactions of responsive and switchable surfaces, covering stimuli-sensitive polymers for drug delivery, surfaces with proteins/cells and application of polymers in medical devices
Front
1
Related titles 3
Switchable and Responsive Surfaces and Materials for Biomedical Applications 4
Copyright 5
Contents 6
List of contributors 10
Woodhead Publishing Series in Biomaterials 12
Introduction 16
Responsive materials 17
Responsive surface modification 17
Responsive surface-biological system interactions 17
Multidisplinary research toward different biomedical applications 17
References 18
Part One -
20
1 - Thermo-responsive polymers: structure and design of smart materials 22
1.1 Introduction 22
1.2 Thermo-responsive polymers and their characteristics 23
1.3 Types of thermo-responsive polymers 25
1.4 Physical forms of switchable materials and their applications 39
1.5 Summary 49
References 50
2 - Environmentally responsive polyelectrolytes and zwitterionic polymers 64
2.1 Introduction 64
2.2 Monomer subunits and polymerization approaches 65
2.3 General solution properties 68
2.4 Stimuli-induced changes and their applications 71
2.5 Future trends 77
2.6 Sources of further information 77
References 78
3 - Peptide-based switchable and responsive surfaces 84
3.1 Introduction 84
3.2 Preparation of peptide surfaces 87
3.3 Responsive peptide surfaces 91
3.4 Peptides attached to responsive surfaces 96
3.5 Protein surfaces 100
3.6 Physical properties and characterisation 102
3.7 Emerging applications 107
3.8 Future trends 108
References 109
4 - Photonic sensitive switchable materials 112
4.1 Introduction 112
4.2 Photonic sensitive switchable materials 113
4.3 Potential applications 118
4.4 Conclusions and future trends 130
References 131
5 - Responsive polymer brushes for biomedical applications 138
5.1 Introduction 138
5.2 Brush architecture 142
5.3 Types of responsive polymer brushes 143
5.4 Biomedical applications 150
5.5 Summary and future trends 157
References 160
6 - Preparation and analysis of switchable copolymers for biomedical application 166
6.1 Introduction 166
6.2 Switchable copolymer coatings 166
6.3 Advanced analytical techniques 172
6.4 Future trends 180
6.5 Sources of further information 180
References 180
Part Two -
184
7 - Interaction of switchable biomaterials surfaces with proteins 186
7.1 Introduction 186
7.2 Protein adsorption on surfaces 187
7.3 Protein adsorption on thermo-responsive surfaces 188
7.4 Protein adsorption on pH and/or ionic strength-responsive surfaces 193
7.5 Protein adsorption on other responsive surfaces 197
7.6 Synergistic effect of surface chemistry and nanostructures on protein adsorption 199
7.7 Aspects for future research 200
Acknowledgments 201
References 202
8 - Interaction of responsive/switchable surfaces with cells 208
8.1 Introduction 208
8.2 Controlling stem cell behavior 209
8.3 Interfacial properties 210
8.4 Physical behavior 213
8.5 Future trends 217
References 218
Further reading 220
9 - Temperature-responsive polymers for cell culture and tissue engineering applications 222
9.1 Introduction 222
9.2 Methods for preparing temperature-responsive cell culture surfaces (TRCSs) and their characteristics 223
9.3 Cell sheet-based regenerative medicine 239
9.4 Future application of temperature-responsive cell culture surface to support and promote regenerative medicine field 242
References 244
10 - Stimuli-sensitive polymers for drug delivery and diagnostic systems interacting with biosurfaces 254
10.1 Introduction 254
10.2 Polymers sensitive to body’s internal stimuli 255
10.3 Polymers sensitive to the body’s external stimuli 264
10.4 Future trends 270
References 271
11 - Application of responsive polymers in implantable medical devices and biosensors 278
11.1 Introduction 278
11.2 Biocompatibility of medical devices and responsive polymers 279
11.3 Cardiovascular devices 281
11.4 Drug delivery/infection control coatings and devices 288
11.5 Surgical devices 290
11.6 Dental and orthopedic devices 293
11.7 Ophthalmic devices 295
11.8 Respiratory devices 297
11.9 Gastrointestinal devices 298
11.10 Urogenital devices/urinary devices 298
11.11 Insulin delivery devices for diabetes management 299
11.12 Biosensors 300
11.13 Summary 306
References 307
Index 318
Woodhead Publishing Series in Biomaterials
Edited by J. F. Kennedy, G. O. Phillips and P. A. Williams
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R. Bibb
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Edited by K. De Smet, P. Campbell and C. Van Der Straeten
J. Basu and J. W. Ludlow
Edited by T. J. Webster
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Edited by A. Inmann and D. Hodgins
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Edited by Y. (Norman) Zhou and M. D. Breyen
Edited by R. Narayan
Edited by A. K. Gaharwar, S. Sant, M. J. Hancock and S. A. Hacking
Edited by A. J. Ruys
Edited by V. Salih
Edited by P. Prokopovich
Edited by Y. Yan
Edited by X.-J. James Li and Y. Zhou
Edited by J. T. Walker
Edited by P. Morris
Edited by M. Jaffe, W. Hammond, P. Tolias and T. Arinzeh
Edited by J. Paolo Davim
Edited by K. Park
E. P. Ivanova, K. Bazaka and R. J. Crawford
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Erscheint lt. Verlag | 11.12.2014 |
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Sprache | englisch |
Themenwelt | Medizin / Pharmazie ► Pflege |
Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Orthopädie | |
Technik ► Maschinenbau | |
Technik ► Medizintechnik | |
ISBN-10 | 0-85709-717-2 / 0857097172 |
ISBN-13 | 978-0-85709-717-0 / 9780857097170 |
Haben Sie eine Frage zum Produkt? |
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Größe: 9,6 MB
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