Disorders of Mineral Metabolism (eBook)

Trace Minerals

Felix Bronner, Jack W. Coburn (Herausgeber)

eBook Download: PDF

2014 | 1. Auflage
516 Seiten
Elsevier Science (Verlag)
978-1-4832-6587-2 (ISBN)

Infos

Disorders of Mineral Metabolism, Volume I: Trace Minerals covers the pathophysiology of clinically relevant minerals and elements. This volume focuses on minerals whose average daily intake is under 50 mg. This text is composed of 12 chapters that tackle the clinical relevance and essentiality of various trace minerals in the human body, with particular emphasis on the disorders due to their abnormal metabolism. The trace mineral and elements considered in this volume include iron, coppers, zinc, lead, nickel, manganese, chromium, molybdenum, cadmium, aluminum, tin, lithium, and fluoride. Each chapter discusses the properties, body requirements, analysis, nutritional interactions, and toxicity of the mineral. This book will prove useful to biochemists, pathophysiologists, and workers in the medical field.

Inhalt

Front Cover 1
Trace Minerals 4
Copyright Page 5
Table of Contents 6
List of Contributors 12
Preface 14
Contents of Other Volumes 16
Chapter 1. Iron 18
I. INORGANIC BIOCHEMISTRY 19
II. IRON-CONTAINING PROTEINS 19
III. IRON ABSORPTION 26
IV. INTERNAL METABOLISM 28
V. METHODS USED FOR CLINICAL INVESTIGATION 35
VI. IRON DEFICIENCY 40
VII. IRON OVERLOAD 49
VIII. METABOLIC ABERRATIONS 54
REFERENCES 59
Chapter 2. Copper 76
I. NORMAL COPPER METABOLISM 77
II. ABNORMAL COPPER METABOLISM 89
REFERENCES 103
Chapter 3. Zinc in Human Nutrition 110
I. INTRODUCTION 111
II. BIOCHEMICAL FUNCTIONS 113
III. EXPERIMENTAL DEFICIENCY IN LABORATORY ANIMALS 116
IV. ZINC METABOLISM 120
VI. ASSESSMENT OF ZINC NUTRITURE 129
VI. ZINC IN FOODS 131
VII. ZINC REQUIREMENTS 132
VIII. HUMAN ZINC DEFICIENCY 137
IX. EXPERIMENTAL ZINC DEFICIENCY IN MAN 153
X. NUTRITIONAL INTERACTIONS AND TOXICITY 155
REFERENCES 157
Chapter 4. Lead 176
I. INTRODUCTION 177
II. ENVIRONMENTAL SOURCES AND TRANSPORT OF LEAD 177
III. HUMAN EXPOSURE AND METABOLISM 179
IV. CELLULAR REACTIONS TO LEAD 183
V. NEUROLOGICAL EFFECTS 188
VI. HEMATOLOGICAL EFFECTS 194
VII. RENAL EFFECTS 197
VIII. EFFECTS OF LEAD ON REPRODUCTION AND DEVELOPMENT 200
IX. EFFECTS ON THE IMMUNE SYSTEM 201
X. INTERACTIONS WITH OTHER MINERALS 202
XI. LEAD IN BONE AND TEETH 204
XII. CLINICAL RECOGNITION OF LEAD TOXICITY 204
XIII. ESSENTIALITY OF LEAD 206
XIV. TREATMENT OF LEAD TOXICITY 207
REFERENCES 207
Chapter 5. Nickel 218
I. INTRODUCTION 219
II. NICKEL METABOLISM 219
III. NICKEL CARBONYL POISONING 225
IV. NICKEL CARCINOGENESIS 228
V. OTHER ASPECTS OF NICKEL TOXICOLOGY 231
VI. SUMMARY 239
REFERENCES 239
Chapter 6. Manganese 250
I. INTRODUCTION 251
II. ANALYSES OF MN IN BIOLOGICAL MATERIALS 252
III. METABOLISM OF MN IN VITRO 254
IV. MN REQUIREMENTS IN NORMAL NUTRITION 255
V. ABSORPTION AND EXCRETION OF MN 263
VI. MN TURNOVER—SPECIFICITY 265
VII. MN DEFICIENCY 268
VIII. MN EXCESS 270
IX. SUSCEPTIBILITY TO MN POISONING 279
X. CONCLUSIONS AND SUMMARY 281
REFERENCES 281
Chapter 7. Chromium 288
I. BIOLOGICAL ROLE OF CHROMIUM IN MAMMALS 289
II. CHROMIUM METABOLISM 294
III. HUMAN CHROMIUM NUTRITION AND DEFICIENCY 297
IV. CONCLUDING REMARKS 305
ACKNOWLEDGMENTS 306
REFERENCES 306
Chapter 8. Molybdenum 312
I. INTRODUCTION 312
II. DIETARY INTAKE AND BODY BURDEN 313
III. Essentiality 315
IV. BIOCHEMISTRY 317
V. PHARMACOLOGY 320
VI. TOXICITY 325
REFERENCES 328
Chapter 9. Cadmium 334
I. OCCURRENCE AND EXPOSURE 335
II. REVIEW OF EFFECTS 340
III. METABOLISM 344
IV. CADMIUM-INDUCED RENAL DAMAGE 352
V. EFFECTS ON VITAMIN D METABOLISM 356
VI. EFFECTS ON BONES 357
REFERENCES 363
Chapter 10. Aluminum and Tin 370
I. ALUMINUM 370
II. TIN 377
REFERENCES 380
Chapter 11. Lithium 386
I. CHEMISTRY 387
II. BIOLOGY 388
III. PHARMACOKINETICS 394
IV. INTERACTIONS OF LITHIUM WITH SPECIFIC HOMEOSTATIC SYSTEMS 400
REFERENCES 436
Chapter 12. Fluoride 456
I. INTRODUCTION 457
II. FLUORIDE INTAKE 457
III. ABSORPTION OF FLUORIDE 460
IV. DISTRIBUTION 464
V. SKELETAL DEPOSITION: FLUORIDE, A BONE SEEKER 472
VI. MOBILIZATION 476
VII. EXCRETION 478
VIII. PREGNANCY AND THE FETUS 483
IX. ESSENTIALITY 484
X. CYCLIC ADENOSINE MONOPHOSPHATE (cAMP) 485
XI. OSTEOPOROSIS 485
XII. OTOSCLEROSIS 486
XIII. SOME TOXIC FLUORIDE EFFECTS IN MAN 486
XIV. ORGANIC FLUORIDE 489
ACKNOWLEDGMENT 489
REFERENCES 489
Index 502

Produkt-Details

• Erscheint lt. Verlag: 10.5.2014
• Sprache: englisch
• Themenwelt: Sachbuch/Ratgeber ► Gesundheit / Leben / Psychologie ► Krankheiten / Heilverfahren
• Themenwelt: Medizin / Pharmazie ► Allgemeines / Lexika
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Themenwelt: Naturwissenschaften ► Physik / Astronomie ► Angewandte Physik
• Themenwelt: Technik
• ISBN-10: 1-4832-6587-0 / 1483265870
• ISBN-13: 978-1-4832-6587-2 / 9781483265872