Nervous System (eBook)

Autonomic Nervous System Drugs

Frederick G. Hofmann, Walter S. Root (Herausgeber)

eBook Download: PDF

2013 | 1. Auflage
534 Seiten
Elsevier Science (Verlag)
978-1-4832-7294-8 (ISBN)

Infos

Physiological Pharmacology: A Comprehensive Treatise, Volume III: The Nervous System - Part C: Autonomic Nervous System Drugs focuses on the effects of drugs on the nervous system, including cardiovascular effects and metabolism. The selection first offers information on the cardiovascular effects of choline esters and the effects of choline esters on smooth muscles and secretions. Topics include actions of acetylcholine, physiological role of choline esters, and actions of cholinergic drugs on smooth muscles and secretions. The book also takes a look at the pharmacologic, toxicologic, and therapeutic properties of anticholinesterase agents, including the chemistry and metabolism of anticholinesterase substances and mechanisms of action of anticholinesterase agents and role of cholinesterases. The publication examines muscarinic blocking drugs and ganglion-blocking drugs. Discussions focus on actions on the secretory glands and cardiovascular system; distribution, metabolism, and excretion of atropine; substances that block ganglionic transmission; and cardiovascular effects. The text also elaborates on neuromuscular blocking drugs. The selection is a dependable reference for readers interested in the effects of drugs on the nervous system.

Inhalt

Front Cover 1
The Nervous System – Part C: Autonomic Nervous System Drugs 4
Copyright Page 5
Table of Contents 10
Contributors to Volume Ill 6
Foreword 8
Contents of Previous Volumes 12
Part I: Cholinergic Drugs 16
Chapter A. Cardiovascular Effects of Choline Esters 16
I. Introduction 16
II. Actions of Acetylcholine 20
III. Esters Related to Acetylcholine 49
IV. On the Physiological Role of Choline Esters 79
References 81
Chapter B. Effects of Choline Esters on Smooth Muscle and Secretions 112
I. Introduction 112
II. The Actions of Cholinergic Drugs on Smooth Muscle 112
III. The Action of Cholinergic Drugs on Secretions 147
References 161
Chapter C. Pharmacologic, Toxicologic, and Therapeutic Properties of Anticholinesterase Agents 178
I. Introduction 179
II. Activities of Cholinesterases, Their Inhibition and Reactivation 182
III. Distribution of Cholinesterases 191
IV. Distribution of Choline Acetylase and of Acetylcholine 197
V. Chemistry and Metabolism of Anticholinesterase Substances 199
VI. Special Pharmacology of Anticholinesterases 210
VII. Therapeutics 261
VIII. Toxicity and its Treatment 265
IX. Mechanisms of Action of Anticholinesterase Agents and Role of Cholinesterases 273
References 278
Part II: Cholinergic Blocking Drugs 338
Chapter A. Muscarinic Blocking Drugs 338
I. Introduction 339
II. Sources 340
III. History 341
IV. Chemistry 341
V. Mechanism of Action 343
VI. Actions on the Secretory Glands 345
VII. Actions on Smooth Muscle 349
VIII. Actions on the Cardiovascular System 360
IX. Actions on the Central Nervous System 362
X. Actions on Other Nervous Tissues 368
XI. Distribution, Metabolism, and Excretion of Atropine 370
References 372
Chapter B. Ganglion-Blocking Drugs 378
I. Introduction 378
II. Substances Which Block Ganglionic Transmission 379
III. Effects of Ganglion Blockade 380
IV. Mode of Action 381
V. Cardiovascular Effects 385
VI. Selective Blockade of Sympathetic and Parasympathetic Ganglia 392
VII. Absorption, Distribution, and Excretion 392
VIII. Side Effects 394
References 395
Chapter C. Neuromuscular Blocking Drugs 404
I. Physiology of Neuromuscular Transmission 404
II. Causes of Neuromuscular Block 407
III. Neuromuscular Blocking Agents that Act Presynaptically 411
IV. Neuromuscular Blocking Agents that Act Postsynaptically 414
References 471
AUTHOR INDEX 476
SUBJECT INDEX 514

Produkt-Details

• Erscheint lt. Verlag: 22.10.2013
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie
• ISBN-10: 1-4832-7294-X / 148327294X
• ISBN-13: 978-1-4832-7294-8 / 9781483272948