Neurotransmitters, Receptors (eBook)

Proceedings of the 8th International Congress of Pharmacology, Tokyo, 1981

S. Ebashi, Y. Hagihara, H. Yoshida (Herausgeber)

eBook Download: PDF

2013 | 1. Auflage
342 Seiten
Elsevier Science (Verlag)
978-1-4831-4847-2 (ISBN)

Infos

Advances in Pharmacology and Therapeutics II, Volume 2: Neurotransmitters-Receptors is the second of a six-volume compilation of the scientific papers of invited speakers of the Eighth International Congress of Pharmacology. Organized into seven parts, this book begins with an invited lecture on the kinetic analysis of the neuronal and extraneuronal uptake and metabolism of catecholamines. Subsequent parts discuss the regulation of receptor-mediated events; presynaptic receptors in the peripheral and central nervous system; neurotransmitters; and receptor antibodies. The isolated nervous systems in the research of neurotransmission and trophic interactions between nerve and muscle are also discussed.

Inhalt

Front Cover 1
Neurotransmitters Receptors 4
Copyright Page 5
Table of Contents 6
Introduction 10
Part 1: Kinetic Analysis of the Neuronal and Extraneuronal Uptake and Metabolism of Catecholamines 12
Chapter 1. Kinetic Analysis of the Neuronal and Extraneuronal Uptake and Metabolism of Catecholamines 14
ABSTRACT 14
KEYWORDS 14
1. INTRODUCTION 14
2. The neuronal pump and enzyme system 15
3. The rate constants for the efflux of metabolites of catecholamines 18
4. The extraneuronal pump and enzyme system 20
5. Are there different biophases for alpha- and beta-adrenoceptors? 24
6. Extraneuronal compartments as a site of action rather than as a site of loss 25
7. Conclusions 25
REFERENCES 26
Part 2: Regulation of Receptor-Mediated Events, including Sub- and Supersensitivity 30
Chapter 2. Chronic Antidepressant Administration and Changes in 3H-imipramine Binding and Brain Receptors 32
The high-affinity —3H-imipramine binding site 32
The effect of chronic tricyclic antidepressant administration on the binding of 3H-imipramine and other ligands 34
Effects of chronic administration of non-tricyclic antidepressant drugs 35
Effects of chronic and subacute applications of non-drug antidepressant therapies 36
Conclusions 37
REFERENCES 37
Chapter 2. Up- and Down-regulation of Noradrenergic Receptor Systems in Brain: Molecular Mechanisms and Physiological Significance 40
ABSTRACT 40
KEY WORDS 40
THE NOREPINEPHRINE (NE) RECEPTOR COUPLED ADENYLATE CYCLASE SYSTEM IN BRAIN TISSUE 41
CHANGES IN SENSITIVITY OF THE NE RECEPTOR COUPLED ADENYLATE CYCLASE SYSTEM IN BRAIN AS A CONSEQUENCE OF CHANGES IN NORADRENERGIC INPUT 41
MOLECULAR MECHANISMS UNDERLYING SUPERSENSITIVITY AND SUBSENSITIVITY OF THE NE RECEPTOR COUPLED ADENYLATE CYCLASE SYSTEM IN BRAIN 43
CONCLUSIONS 46
ACKNOWLEDGEMENTS 47
REFERENCES 47
Chapter 3. Dopamine Receptors and Dopaminergic Supersensitivity 52
1. TERMINOLOGY FOR DOPAMINE-SENSITIVE SITES 52
2. BEHAVIOURAL DOPAMINERGIC SUPERSENSITIVITY AFTER LONG-TERM NEUROLEPTICS 52
3. BIOCHEMICAL AND ELECTROPHYSIOLOGICAL ASPECTS OF DOPAMINERGIC SUPERSENSITIVITY 53
4. DOPAMINE RECEPTORS AND NEUROLEPTIC-INDUCED DOPAMINERGIC SUPERSENSITIVITY 55
5. DOPAMINERGIC SUPERSENSITIVITY AFTER DENERVATION OF DOPAMINE NEURONES 55
6. RELATION BETWEEN DENSITY OF D2 RECEPTORS AND DOPAMINE SENSITIVITY 56
7. REVERSAL OF ELEVATED D2 RECEPTORS: EFFECTS OF DOPAMINE AGONISTS 57
ACKNOWLEDGEMENTS 58
REFERENCES 58
Chapter 4. Regulation of Acetylcholine Receptors 62
ABSTRACT 62
KEYWORDS 62
INTRODUCTION 62
REFERENCES 65
Chapter 5. Lipids and the Receptor Mediated Release of Histamine 68
ABSTRACT 68
KEY WORDS 68
INTRODUCTION 68
PHOSPHOLIPID METHYLATION IN MEMBRANES 69
PHOSPHOLIPID METHYLATION AND RELEASE OF HISTAMINE FROM MAST CELLS 70
RBL VARIANTS, PHOSPHOLIPID METHYLATION AND HISTAMINE RELEASE 75
CONCLUSION 77
REFERENCES 77
Chapter 6. Role of Phospholipid in the Transmitter-Induced Synthesis of Cyclic GMP in Nervous Tissue 80
ABSTRACT 80
KEYWORDS 80
INTRODUCTION 80
RESULTS 81
DISCUSSION 87
ACKNOWLEDGMENT 88
REFERENCES 88
Part 3: Presynaptic Receptors in the Peripheral and Central Nervous System 90
Chapter 7. The Role of Presynaptic Receptors in the Modulation of Neurotransmission 92
ABSTRACT 92
KEYWORDS 92
INTRODUCTION 92
CONCLUSIONS 100
REFERENCES 101
Chapter 8. Cholinergic-Adrenergic Interactions at the Presynaptic Level as Studied in the Heart 104
KEY WORDS 104
INTRODUCTION 104
METHOD: THE ISOLATED PERFUSED RABBIT ATRIA PREPARATION 106
RESULTS AND DISCUSSION 109
ACKNOWLEDGEMENTS 113
REFERENCES 113
Chapter 9. Evidence for Transsynaptic Modulation of Adrenergic Transmitter Secretion 114
ABSTRACT 114
KEYWORDS 114
INTRODUCTION 114
PROSTAGLANDIN E2 AS TRANSSYNAPTIC MODULATOR OF NORADRENALINE SECRETION 115
ADENOSINE AS TRANSSYNAPTIC MODULATOR OF NORADRENALINE SECRETION 116
SYNAPTIC AUTOINHIBITION VERSUS TRANSSYNAPTIC MODULATION OF NORADRENALINE SECRETION 116
ACKNOWLEDGEMENTS 119
REFERENCES 120
Chapter 10. Site(s) and Ionic Mechanisms in Facilitation and a-Autoinhibition of 3H-Noradrenaline Secretion in Guinea-Pig Vas Deferens 122
ABSTRACT 122
KEYWORDS 122
INTRODUCTION 122
METHODS 124
RESULTS AND DISCUSSION 124
CONCLUSIONS 130
REFERENCES 131
Chapter 11. The Time Course of the Development and Persistence of the Autoinhibitory Effect in Noradrenergic Transmission 132
ABSTRACT 132
INTRODUCTION 132
METHODS 133
RESULTS 134
DISCUSSION 137
REFERENCES 140
Chapter 12. Presynaptic Autoreceptors 142
ABSTRACT 142
KEYWORDS 142
INTRODUCTION 142
BASIC EVIDENCE 143
FURTHER ANALYSIS 144
RECEPTOR COMPARISON 146
ACKNOWLEDGEMENT 148
REFERENCES 148
Part 4: Neurotransmitters: New Concepts and Strategies 152
Chapter 13. In vitro Analysis of Transmitters:the Brain 154
ABSTRACT 154
INTRODUCTION 155
INTRACELLULAR RECORDING 156
CONCLUDING REMARKS 161
REFERENCES 161
Chapter 14. Modulation of Substance P Release and Voltage-Dependent Ion Channels in Primary Sensory Neurons 166
Abstract 166
Key words 166
Substance P as a possible transmitter in sensory neurons 167
Inhibition of substance P release from sensory neurons 169
Enhancement of substance P release from sensory neurons 170
Chemosensitivity of sensory neurons in dissociated cell culture 171
Discussion 174
REFERENCES 175
Chapter 15. Monoclonal Antibodies and Neurotransmitters 178
ABSTRACT 178
KEYWORDS 178
INTRODUCTION 178
METHODS 179
ACKNOWLEDGEMENTS 185
REFERENCES 186
Chapter 16. Functional Implications of Coexistence of Peptides and Classical Transmitters: Studies on Exocrine Glands 188
ABSTRACT 188
KEY WORDS 188
INTRODUCTION 189
ESTABLISHMENT OF PEPTIDE-CLASSICAL TRANSMITTER COEXISTENCE 189
SUBCELLULAR STORAGE OF VIP AND ACETYLCHOLINE 190
SUPPLY OF VIP AND ACTEYLCHOLINE TO NERVE ENDINGS 192
RELEASE OF VIP AND ACETYLCHOLINE UPON NERVE STIMULATION 192
EFFECTS OF PHARMACOLOGICAL TREATMENT 192
EFFECTS OF EXOGENOUSLY ADMINISTERED VIP AND ACETYLCHOLINE 193
INACTIVATION MECHANISMS 195
VIP – A COEXISTING TRANSMITTER OR MODULATOR? 195
FUNCTIONAL ASPECTS ON THE APP-LIKE PEPTIDE IN NORADRENERGIC NEURONS 196
ACKNOWLEDGEMENTS 196
REFERENCES 196
Chapter 17. Recombinant DNA Strategies of Neurotransmitter Research 200
SUMMARY 200
INTRODUCTION 200
MATERIALS AND METHODS 202
RESULTS 202
REFERENCES 207
Part 5: Prospectives on Receptor Antibodies 210
Chapter 18. Acetylcholine Receptor Antibodies 212
ABSTRACT 212
KEYWORDS 212
STRUCTURE AND FUNCTION OF AChR 214
MONOCLONAL ANTIBODIES 215
CONCLUSION 217
REFERENCES 218
Chapter 19. Insulin Receptor Structure and Antibodies 220
ABSTRACT 220
KEYWORDS 220
INTRODUCTION 220
REFERENCES 225
Chapter 20. Thyrotropin Receptor Antibodies 228
ABSTRACT 228
INTRODUCTION 229
REFERENCES 237
Chapter 21. Distinct Characterstics of IgM-Fc and IgG-Fc Receptors in Nature, Expression and Modulation 240
ABSTRACT 240
KEYWORDS 240
INTRODUCTION 240
DIFFERENT EXPRESSIONS OF FcµR and Fc.R IN CULTURE 241
SUSCEPTIBILITY TO ENZYMATIC DEGRADATION AND MODULATION BY METABOLIC INHIBITORS OF FcµR and Fc.R 242
DIFFERENT SENSITIVITY OF Tµ AND T. CELLS TO CORTICOSTEROID AND INVERTED CIRCADIAN RHYTHMS RELATED WITH PLASMA CORTICOSTEROID LEVELS 244
EFFECT OF INTERFERON ON THE EXPRESSIONS OF FcµR AND Fc.R 245
CORRELATION OF FcR MODIFICATIONS AND MODULATIONS OF IMMUNE RESPONSES BY INTERFERON 247
SUMMARY 248
REFERENCES 249
Part 6: Isolated Nervous Systems in the Research of Neurotransmission 252
Chapter 22. Isolated Nervous Systems in the Research of Neurotransmission 254
Chapter 23. Morphological and Electrophysiological Properties of Dissociated Retinal Neurons 256
ABSTRACT 256
KEYWORDS 256
INTRODUCTION 256
METHODS 257
RESULTS 257
ACKNOWLEDGEMENT 264
REFERENCES 264
Chapter 24. Electrophysiology of Mammalian Spinal Cord and Sympathetic Ganglia in vitro 266
ABSTRACT 266
KEYWORDS 266
INTRODUCTION 266
SPINAL CORD PREPARATION ISOLATED FROM THE NEWBORN RAT 266
PREVERTEBRAL SYMPATHETIC GANGLIA ISOLATED FROM THE GUINEA PIG 270
ACKNOWLEDGEMENT 271
REFERENCES 271
Chapter 25. Electrophysiological and Pharmacological Investigation of Superfused and Intraarterially Perfused Spinal Cord Preparations of the Kitten 272
ABSTRACT 272
KEYWORDS 272
THE USE OP THE PERFUSED KITTEN'S SPINAL OORD 272
MODE OP JUNCTIONAL TRANSMISSION 275
SPONTANEOUS SYNAPTIC ACTIVITY 275
QUANTAL NATURE OP EVOKED RELEASE 279
REFERENCES 279
Chapter 26. Dendrodendritic Inhibition Studied with Intracellular Recording 280
ABSTRACT 280
KEYWORDS 280
INTRODUCTION 280
RESULTS 281
DISCUSSION 283
REFERENCES 284
Chapter 27. Quantal Nature of Excitatory Postsynaptic Potentials in the Hippocampus 286
ABSTRACT 286
KEYWORDS 286
RECORDING OF ELECTRICAL ACTIVITY FROM BRAIN SLICES 286
ULTRASTRUCTURE AND ATP CONTENTS OF BRAIN SLICES 287
ELECTRICAL ACTIVITIES OF SLICES PREPARED FROM OTHER PORTIONS OF THE MAMMALIAN BRAIN 287
QUANTAL ANALYSIS OF THE EPSP'S 288
GENERAL CONCUSIONS 289
ACKNOWLEDGMENT 289
REFERENCES 289
Part 7: Trophic Interactions between Nerve and Muscle 292
Chapter 28. Studies on Denervation, Disuse and Motor Nerve Sprouting in Mammalian Muscle 294
ABSTRACT 294
KEYWORDS 294
INTRODUCTION 294
RESULTS AND DISCUSSION 295
ACKNOWLEDGEMENT 300
REFERENCES 300
Chapter 29. Sciatin: Purification, Characterization, Localization and Biological Properties of a Myotrophic Protein from Sciatic Nerves 304
ABSTRACT 304
KEYWORDS 304
INTRODUCTION 304
PURIFICATION AND CHARACTERIZATION OF SCIATIN 305
PRODUCTION OF SPECIFIC ANTIBODIES AGAINST SCIATIN 306
PRESENCE OF SCIATIN IN CHICK EMBRYO EXTRACT 306
IMMUNOCYTOCHEMICAL LOCALIZATION OF SCIATIN IN CHICKEN NEURAL TISSUES 306
TISSUE DISTRIBUTION, AXONAL TRANSPORT AND RELEASE OF SCIATIN 308
PRESENCE OF SCIATIN IN CHICKEN SERUM 308
ACKNOWLEDGEMENTS 309
REFERENCES 309
Chapter 30. The Neurotrophic Substance Affecting Muscle Membrane Properties Responsible for the Generation of Action Potential 312
ABSTRACT 312
KEYWORDS 312
INTRODUCTION 312
BIOASSAY OF TROPHIC ACTIVITY 313
DISTRIBUTION OF TROPHIC ACTIVITY IN VARIOUS TISSUES 314
PARTIAL PURIFICATION OF TROPHIC SUBSTANCE 315
EFFECTS OF TROPHIC SUBSTANCE ON DEVELOPING MYOTUBES 315
PROPERTIES OF TROPHIC SUBSTANCE 317
ACKNOWLEDGEMENT 317
REFERENCES 317
Chapter 31. Synaptic Repression at Cholinergic Synapses in Tissue Culture 318
ABSTRACT 318
KEYWORDS 318
INTRODUCTION 318
HYBRID-MYOTUBE SYNAPSES: EFFECTS OF DEPOLARIZATION 319
CILIARY NEURON-MYOTUBE SYNAPSES: EFFECTS OF CELLULAR COMPETITION 320
DISCUSSION 321
ACKNOWLEDGMENTS 322
REFERENCES 323
Chapter 32. Facilitation in vitro Growth of Neurites from Central and Ganglionic Neurons by Factors in Conditioned Medium, Serum and Tissue 324
ABSTRACT 324
KEYWORDS 324
ACKNOWLEDGEMENT 329
REFERENCES 329
Index 330

Produkt-Details

• Erscheint lt. Verlag: 22.10.2013
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie
• ISBN-10: 1-4831-4847-5 / 1483148475
• ISBN-13: 978-1-4831-4847-2 / 9781483148472