Pharmacology of Cardiac Function (eBook)

Section of Pharmacology of the International Union of Physiological Sciences

Otto Krayer (Herausgeber)

eBook Download: PDF

2013 | 1. Auflage
160 Seiten
Elsevier Science (Verlag)
978-1-4831-6452-6 (ISBN)

Infos

Pharmacology of Cardiac Function brings together the proceedings of the Second International Pharmacological Meeting of the International Union of Physiological Sciences, held in Prague, Czechoslovakia, on August 20-23, 1963. The meeting provided a forum for discussing advances in the understanding of the pharmacology of cardiac function and addressed topics ranging from the link between muscle physiology and the heart to the development of tension in cardiac muscle. This volume is comprised of 21 chapters and begins with an overview of the structural aspects of contraction in cardiac and skeletal muscle, followed by a description of muscle physiology and its effect on the heart. The next section deals with the effects of drugs on the interval-strength relationship of heart muscle, paying particular attention to acetylstrophanthidin, levarterenol, and carbacliol as well as metabolic inhibitors. The nature of the restitution process occurring between beats in cardiac muscle is also considered. Subsequent chapters explore how the heart is affected by the action of the vagus and of acetylcholine and other parasympathomimetic drugs; membrane effects of epinephrine and digitalis; and the mode of action of antifibrillatory drugs. This book will be of particular value to pharmacologists and physiologists.

Inhalt

Front Cover 1
Pharmacology of Cardiac Function 4
Copyright Page 5
Table of Contents 6
PART I: MUSCLE CONTRACTION 10
Chapter 1. Introductory Remarks 12
Chapter 2. Structural Aspects of Contraction in Cardiac and Skeletal Muscle 14
REFERENCES 17
Chapter 3. Muscle Physiology and the Heart 18
REFERENCES 23
Chapter 4. The Development of Tension in Cardiac Muscle 24
REFERENCES 32
Chapter 5. Electrolytes and Myocardial ContractilitY 34
I. THE IMPORTANCE OF CALCIUM FOR THE RISING STEEPNESS OF THE ISOMETRIC CONTRACTION OF HEART MUSCLE 34
II. INFLUENCE ON PEAK TIME (AND OSCILLATORY CONTRACTIONS) 39
III. INOTROPIC ACTIONS DUE TO AN INCREASE IN CONTRACTION STEEPNESS 43
REFERENCES 50
PART II: EFFECTS OF DRUGS ON THE INTERVAL-STRENGTH RELATIONSHIP OF HEART MUSCLE 52
Chapter 6. Importance of the Interval-Strength Relationship for the Evaluation of Cardiac Inotropic Effects of Drugs 54
REFERENCES 61
Chapter 7. Descriptive Analysis of the Interval-Strength Relationship of Heart Muscle 62
REFERENCES 71
Chapter 8. Effects of Acetylstrophanthidin, Levarterenol and Carbacliol on the Interval-Strength Relationship of Heart Muscle 72
REFERENCES 80
Chapter 9. Effects of Metabolic Inhibitors on the Interval-Strength Relationship 82
REFERENCES 85
Chapter 10. Some Comments on the Nature of the Restitution Process Occurring between Beats in Cardiac Muscle 86
REFERENCES 88
Chapter 11. Chairman's Concluding Remarks 90
PART III: IMPULSE GENERATION AND CONDUCTIONWEIDMANN 92
Chapter 12. Introductory Remarks 94
REFERENCES 94
Chapter 13. The Action of the Vagus, of Acetylcholine and Other Parasympathomimetic Drugs on the Heart 96
REFERENCES 101
Chapter 14. Membrane Effects of Epinephrine in the Heart 104
REFERENCES 109
Chapter 15. The Importance of the Norepinephrine Stores for the Action of Various Cardio-active Drugs 110
THE NOREPINEPHRINE STORES AND THEIR COMPARTMENTS 110
MODE AND SITE OF ACTION OF VARIOUS DRUGS 112
REFERENCES 115
Chapter 16. Membrane Effects of Digitalis 118
REFERENCES 119
Chapter 17. Effect of Ouabain on Cardiac Contraction, Action Potential and Cellular Potassium 120
REFERENCES 122
Chapter 18. Mechanism of Fibrillation in a Mathematical Model 124
REFERENCES 127
Chapter 19. The Mode of Action of Antifibrillatory Drugs 128
VENTRICULAR FIBRILLATION 134
REFERENCES 140
Chapter 20. Fibrillatory and Antifibrillatory Drugs 142
FIBRILLATORY DRUGS 143
ANTIFIBRILLATORY DRUGS 146
REFERENCES 148
Chapter 21. Discussion of Dr. West's Paper 152
REFERENCES 157
INDEX 158

Produkt-Details

• Erscheint lt. Verlag: 22.10.2013
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie
• ISBN-10: 1-4831-6452-7 / 1483164527
• ISBN-13: 978-1-4831-6452-6 / 9781483164526