Ingredient X (eBook)

The Production of Effective Drugs

Louis C. Schroeter (Autor)

eBook Download: PDF

2013 | 1. Auflage
166 Seiten
Elsevier Science (Verlag)
978-1-4831-5911-9 (ISBN)

Infos

Ingredient X: The Production of Effective Drugs deals with various aspects of pharmaceutical research and development, with emphasis on the importance of formulation ingredients on drug effectiveness and the role of the pharmaceutical development scientist in designing dosage forms for modern drugs. More than 50 illustrations are used to explain experiments and ''tools of the trade''. This book is comprised of four chapters and opens with an overview of research and development in the pharmaceutical industry, paying particular attention to the kind of work done by scientists according to the degree or level of training. The additives or so-called ''inert'' ingredients used in drug formulation are also considered. The next chapter explains how adding just the right amount of some ''inert'' ingredient-a factor X-can enhance the acceptability of a product to the user. The importance of maintaining drug potency in a dosage form, mainly through refrigeration or storage in cool places, is then discussed. The final chapter looks at the factors to consider to achieve the best possible drug formulation and most effective dosage form, including the safety factor. The need to establish correlations between laboratory quality tests and product performance during the development phase is highlighted. This monograph will be a useful resource for pharmacologists and pharmaceutical development scientists.

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Ingredient X: The Production of Effective Drugs deals with various aspects of pharmaceutical research and development, with emphasis on the importance of formulation ingredients on drug effectiveness and the role of the pharmaceutical development scientist in designing dosage forms for modern drugs. More than 50 illustrations are used to explain experiments and "e;"e;tools of the trade"e;"e;. This book is comprised of four chapters and opens with an overview of research and development in the pharmaceutical industry, paying particular attention to the kind of work done by scientists according to the degree or level of training. The additives or so-called "e;"e;inert"e;"e; ingredients used in drug formulation are also considered. The next chapter explains how adding just the right amount of some "e;"e;inert"e;"e; ingredient-a factor X-can enhance the acceptability of a product to the user. The importance of maintaining drug potency in a dosage form, mainly through refrigeration or storage in cool places, is then discussed. The final chapter looks at the factors to consider to achieve the best possible drug formulation and most effective dosage form, including the safety factor. The need to establish correlations between laboratory quality tests and product performance during the development phase is highlighted. This monograph will be a useful resource for pharmacologists and pharmaceutical development scientists.

Inhalt

Front Cover 1
Ingredient X: The Production of Effective Drugs 4
Copyright Page 5
Table of Contents 6
Preface 8
CHAPTER I. Research And Development (R & D)
DEVELOPMENT 10
TWO KINDS OF RESEARCH 12
TRAINING 13
"INERT" INGREDIENTS 16
UTILITY 20
THE BIG CAKE BAKE 21
A KEY FACTOR 22
BALANCING ACT 28
GROWING OLD 30
TACTICS AND STRATEGY 32
CHAPTER II. Product Acceptability 34
FROM TINCTURES TO TABLETS 34
POROUS BOTTLES 38
HOW SWEET IT IS OR WHO DECIDES THE TASTE 40
ALMOST EVERYBODY LIKES ORANGE 43
A PANEL DECIDES 48
ALAS, THE COLOR IS GONE! 49
THREE DIMENSIONS OF COLOR 51
SQUEEZING TUBES AND POURING GOO 57
THE CREAM "FEELS" GOOD 63
A SHOT IN THE ARM 64
TABLETS FOR CHEWING AND SWALLOWING 67
CHAPTER III. On The Shelf 70
PURITY 70
ACTIVITY 73
STOCKPILES AND DOCTORS' BAGS 74
EARLY WARNING SYSTEM 76
MECHANISMS AND PATHWAYS 81
AIR, AIR — EVERYWHERE 82
OXYGEN SCAVENGERS 86
LIGHTS OUT 88
CHECKING PREDICTIONS 88
CAGES FOR MOLECULES 89
LAYER CAKES 97
BUGS 103
CHAPTER IV. Performance 108
SAFETY FIRST 108
TEST TUBE TESTS 112
ROCKETS AND TABLETS 114
HOSTILE ENVIRONMENT 117
CONTROLLING RELEASE 120
ABSORPTION 123
LITTLE PILLS 126
CROSSOVER TESTS 127
RADIOACTIVE LABELS 131
ACTIVITY AND RESPONSE 136
WHAT'S AVAILABLE 137
PLACEBO EFFECTS AND CLINICAL TESTS 143
RECIPE FOR QUALITY 144
Appendix: UNITS OF MEASUREMENT, ABBREVIATIONS, AND APPROXIMATE EQUIVALENTS 148
Glossary 150
Subject Index 159

Produkt-Details

• Erscheint lt. Verlag: 22.10.2013
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie
• ISBN-10: 1-4831-5911-6 / 1483159116
• ISBN-13: 978-1-4831-5911-9 / 9781483159119