Progress in Chemical Toxicology (eBook)

Volume 5

Abraham Stolman (Herausgeber)

eBook Download: PDF

2013 | 1. Auflage
406 Seiten
Elsevier Science (Verlag)
978-1-4832-1924-0 (ISBN)

Infos

Progress in Chemical Toxicology, Volume 5 covers topics on the improved isolation and detection procedures and quantitation methods for volatile poisons, stimulants, hallucinogenic drugs, and marihuana. The book discusses the absorption, distribution, and excretion of drugs and poisons and their metabolites; the system for the toxicological analysis of drugs in biological specimens; and the isolation and analysis of phenothiazines. The text also describes the use of fluorescence in toxicology and the toxicology of new synthetic organic polymers used in containers for food, pharmaceutical compounds, and drinkable water. Some microcrystal tests for drugs and advances in polarography as applied to toxicological analysis are also considered. Biochemists, toxicologists, and scientists involved in the study of narcotics will find the book invaluable.

Inhalt

Front Cover 1
Progress in Chemical Toxicology 4
Copyright Page 5
Table of Contents 6
Contributors 10
Preface 12
Contents of Other Volumes 14
Chapter 1. The Absorption, Distribution, and Excretion of Drugs and 
18 
I. Gases and Vapors (Poisons through Inhalation) 19
II. Volatile Liquids (Steam Distillation) 35
III. Drugs Extractable by Organic Solvents from Aqueous Alkaline Solutions 41
V. 2,4,5-Trimethoxyamphetamine (TMA-2) 91
REFERENCES 110
Chapter 2. A System for the Toxicological Analysis of Drugs in Biological Specimens 
118 
I. Introduction 118
II. Procedure for Analysis of Tissue 129
III. Discussion 129
IV. Simplified Wallace Procedure for the Identification of Drugs 150
V. Analysis of Urine Samples for Drugs (G4) 152
VI. Determination of Total Morphine in Urine (GI) 163
REFERENCES 165
Chapter 3. The Phenothiazines 168
I. Introduction 168
II. Materials 169
III. Metabolites 170
IV. Spectrofluorometry 171
V. UV Spectrophotometry 174
VI. Thin-Layer Chromatography 186
VII. Color Reactions 187
VIII. Gastric Contents 187
IX. Soft Tissues 188
X. Interference from the Presence of Other Drugs 192
XI. Phenothiazine Levels in Blood Serum and Urine 194
XII. Summary 201
REFERENCES 201
Chapter 4. Fluorescence in Toxicology 204
I. Introduction 204
II. Fundamentals of Fluorescence Analysis 206
III. Theoretical Aspects of Fluorescence 209
IV. Practical Aspects of Fluorescence 215
V. Applications of Spectrophotofluorometry in Toxicology 224
REFERENCES 283
Chpter 5. Toxicology of New Synthetic Organic Polymers Used in Containers for Food, Pharmaceutical Compounds, and Drinkable Water 
290 
I. Introduction 290
II. Admission Procedure for a Formula 291
III. Discussion and Justification of the Chemical Analytical 
293 
V. Conclusion 307
REFERENCES 308
Chapter 6. Some Microcrystal Tests for Drugs 310
I. Introduction 310
II . Apparatus 311
III . Reagents 312
IV. Techniques 315
V. Sample Preparation 316
VI. Remarks Concerning the Tables 317
REFERENCES 383
Chapter 7. Advances in Polarography as Applied toToxicological Analysis 386
I. Introduction 386
II. Oscillographic Polarography 387
III. General Techniques for Alternating Current Polarography 390
IV. Application to Toxicological Analysis 392
REFERENCES 396
Subject Index 398

Produkt-Details

• Erscheint lt. Verlag: 22.10.2013
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie
• ISBN-10: 1-4832-1924-0 / 1483219240
• ISBN-13: 978-1-4832-1924-0 / 9781483219240