Essays in Toxicology (eBook)

Volume 7

Wayland J. Hayes (Herausgeber)

eBook Download: PDF

2013 | 1. Auflage
222 Seiten
Elsevier Science (Verlag)
978-1-4832-1647-8 (ISBN)

Infos

Essays in Toxicology, Volume 7 presents essays on toxicology and related topics. The book presents essays on the effects of toxicants on reproductive performance; an overall view of carcinogenesis from an epidemiological viewpoint and the potentialities and limitations of the epidemiological method in cancer control; and the activity of cytochrome P450 and mixed-function oxidase in target and nontarget organisms. The text also includes essays on the toxicity of hexachlorophene and the use of hexachlorophene as an antibacterial agent; the methodology, dose measurement, and respiratory function assessment in respiratory toxicology; as well as behavioral toxicology, with focus on early warning and worker safety and health. Pharmacologists, biochemists, pathologists, neurophysiologists, epidemiologists, and toxicologists will find the book invaluable.

Inhalt

Front Cover 1
Essays in Toxicology 4
Copyright Page 5
Table of Contents 6
List of Contributors 10
Preface 12
Contents of Previous Volumes 14
Chapter 1. Effects of Toxicants on Reproductive Performance 18
I. INTRODUCTION 19
II. DDT: MYTHICAL MUTAGEN 19
III. CHEMICAL MUTAGENS: THE REAL THING 27
IV. ANTIMETABOLITES 35
V. MITOTIC SPINDLE POISONS 37
VI. SOMATIC ASPECTS 38
VII. CONCLUDING REMARKS 39
REFERENCES 40
Chapter 2. Chronic Toxicology—An Epidemiologist's Approach to the Problem of Carcinogenesis 46
I. INTRODUCTION 47
II. GENERAL PRINCIPLES OF EPIDEMIOLOGICAL STUDIES IN HUMAN CARCINOGENESIS 48
III. ETIOLOGICAL APPROACHES TO HUMAN CANCER BASED ON GEOGRAPHICAL VARIATIONS IN CANCER INCIDENCE 64
IV. EPIDEMIOLOGICAL STUDIES RELATED TO UNUSUAL EXPOSURE TO POTENTIAL CARCINOGENS 74
V. CONCLUSION 84
REFERENCES 85
Chapter 3. Comparative Toxicology: Cytochrome . 450 and Mixed-Function Oxidase Activity in Target and Nontarget Organisms 90
I. INTRODUCTION 90
II. GENERAL FEATURES OF CYTOCHROME . 450 AND THE MICROSOMAL MIXED-FUNCTION OXIDASE SYSTEM OF 
92 
III. RELATIONSHIP OF SPECTRUM FORMATION TO SUBSTRATE ACTIVITY 97
IV. INTRACELLULAR LOCATION OF CYTOCHROME . 450 98
V. OCCURRENCE OF CYTOCHROME . 450 99
VI. EVOLUTIONARY CONSIDERATIONS 104
VII. ROLE OF CYTOCHROME . 450 IN RESISTANCE TO INSECTICIDES 105
VIII. CONCLUSIONS 108
ACKNOWLEDGMENT 109
REFERENCES 109
Chapter 4. Hexachlorophene: Toxicity and Use as an Antibacterial Agent 116
I. INTRODUCTORY REMARKS 116
II. STAPHYLOCOCCUS INFECTIONS IN INFANTS AND USE OF HEXACHLOROPHENE ON INFANTS AND OTHER SEGMENTS OF THE GENERAL POPULATION 118
III. TOXICITY OF HEXACHLOROPHENE IN ANIMALS 122
IV. .UMA. TOXICITY 125
V. SKIN ABSORPTION, HEXACHLOROPHENE BLOOD LEVELS, AND TISSUE LEVELS 127
VI. OTHER TOXIC EFFECTS OF HEXACHLOROPHENE 131
VII. LEGAL RESTRICTIONS OF HEXACHLOROPHENE 132
REFERENCES 133
Chapter 5. Respiratory Toxicology 138
I. INTRODUCTION 138
II. METHODOLOGY 139
III. ESTIMATION OF DOSE 157
IV. RESPIRATORY FUNCTION TESTS 162
V. CONCLUDING REMARKS 169
REFERENCES 170
Chapter 6. Behavioral Toxicology: Early Warning and Worker Safety and Health 172
I. INTRODUCTION 172
II. HISTORICAL DEVELOPMENT OF BEHAVIORAL TOXICOLOGY 174
III. BEHAVIORAL TOXICOLOGY OF INDUSTRIAL CHEMICALS 179
IV. CHEMICAL INTERACTIONS 203
V. DRUG EFFECTS AND INDUSTRIAL SAFETY 205
VI. METHODOLOGICAL PROBLEMS IN BEHAVIORAL TOXICOLOGY RESEARCH 209
VII. FUTURE OF BEHAVIORAL TOXICOLOGY RESEARCH 213
REFERENCES 215
Subject Index 220

Produkt-Details

• Erscheint lt. Verlag: 22.10.2013
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie
• ISBN-10: 1-4832-1647-0 / 1483216470
• ISBN-13: 978-1-4832-1647-8 / 9781483216478