Essays in Toxicology (eBook)

Volume 4

Wayland J. Hayes (Herausgeber)

eBook Download: PDF

2013 | 1. Auflage
230 Seiten
Elsevier Science (Verlag)
978-1-4832-1644-7 (ISBN)

Infos

Essays in Toxicology, Volume 4 covers three essays on habituating drugs, on the kinetics of the active-site-directed irreversible inhibition, and the hidden effects of trace elements. The first essay examines certain dependence-producing drugs; the mechanism of tolerance to barbiturates by changes in drugs metabolism; the distribution of barbiturates to the central nervous system; and the urinary excretion of barbiturates. The formation of morphine from heroin and codeine, and the dealkylation to form normorphine and to reduce naloxone to another compound is also considered in the first essay. The second essay discusses the time-course of enzyme inhibition at single-inhibitor concentrations and the effect of various inhibitor concentrations on the rate constants governing inhibition. The third essay is about the recondite toxicity of trace elements, taking into consideration the effects of these trace elements on body weight, survival, and longevity, clues to mechanisms of toxicity, and the production of chronic diseases simulating human disorders. Toxicologists, oncologists, biochemists, and pharmacologists will find the book invaluable.

Inhalt

Front Cover 
1 
Essays in Toxicology 4
Copyright Page 
5 
Table of Contents 
6 
List of Contribotors 8
Preface 10
Contents of Previons Volnmes 12
Chapter 1. Drug Dependence: Whither the Drug? 14
I. Introduction 14
II. Mechanism of Tolerance to Barbiturates by Changes in Drug Metabolism 16
III, Distribution of Barbiturates to the Central Nervous System 21
IV, Urinary Excretion of Barbiturates 22
V. Unmasking the Culprit–Heroin 25
VI. Metabolism of Morphine 30
VII. Metabolic Transformation of Codeine to Morphine 34
VIII. Metabolism of Naloxone 36
IX. Excretion of Narcotics and Metabolites in Urine 39
X. Transport in Brain 52
XI. Placental Transfer 54
XII. Biliary Excretion 56
XIII. Certain Aspects of Metabolism of .9-Tetrahydro-cannabinol 60
References 62
Chapter 2. Kinetics of Active-Site-Directed Irreversible Inhibition 72
I. Introduction 72
II. Trivial Names and Symbols 75
III. Origins 77
IV. Kinetics 86
References 115
Chapter 3. Recondite Toxicity of Trace Elements 120
I. Introduction 121
II. Specific Considerations 125
III. General Conclusions 128
IV. Recondite Toxicity in Terms of Growth 128
V. Effects on Body Weights of Aged Animals 137
VI. Effects of Trace Elements on Survival and Longevity 137
VII. Effects on Tumors 139
VIII. Longevity and Median Life-Span 142
IX. Other Manifestations of Recondite Toxicity 145
X. Recondite Toxicity of Trace Elements as Expressed by Effects on Reproduction of Rats and Mice 164
XI. Some Clues to Mechanisms of Toxicity 169
XII. Production of Chronic Diseases Stimulating Human Disorders 187
XIII. Recondite Toxicity of Other Metals or Elements in Man 199
XIV. Innate Toxicity from Water 201
XV. Summary and Conclusions 206
References 208
AUTHOR INDEX 214
SUBJECT INDEX 220

Produkt-Details

• Erscheint lt. Verlag: 22.10.2013
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie
• ISBN-10: 1-4832-1644-6 / 1483216446
• ISBN-13: 978-1-4832-1644-7 / 9781483216447