Drug Design (eBook)

Medicinal Chemistry: A Series of Monographs, Vol. 10

E. J. Ariens (Herausgeber)

eBook Download: PDF

2013 | 1. Auflage
446 Seiten
Elsevier Science (Verlag)
978-1-4832-1611-9 (ISBN)

Infos

Drug Design, Volume X covers promising and current developments in drug design. The book discusses procedures as applied in the practice of drug design; the structural aspects of the structure-activity relationships of neuroleptics; and promising perspectives in the highly actual field of bioactive peptides. The text also describes the application of the dynamic systems analysis to the antihypertensive drug action; polymeric drug delivery systems; and the design of biocompatible polymers. The structure-activity relationships of insect repellents as a basis for the design of such agents, as well as the approaches to the multivariate data analysis in structure-activity relationships, which is an essential aspect of drug design, are also encompassed. Chemists, pharmacologists, bioengineers, and people involved in drug design and manufacture will find the book invaluable.

Inhalt

Front Cover 1
Drug Design 4
Copyright Page 5
Table of Contents 6
List of Contributors 10
Preface 12
Chapter 1. Practical Procedures in Drug Design 14
I. Introduction 14
II. General Aspects of Drug Development 15
III. Procedures in Drug Design 17
IV. Application of the Theory of Sets to Drug Design 20
V. Drug Design in Practice 30
VI. Conclusion 80
References 80
Chapter 2. Structural Aspects of the Structure-Activity Relationships of Neuroleptics: Principles and Methods 84
I. Introduction 85
II. Conformational Analysis 86
III. Determination of Molecular Structure 90
IV. Description and Comparison of Molecular Structures 110
V. Summary and Conclusions 127
ACKNOWLEDGMENTS 128
References 128
Chapter 3. Bridging the Gap between Bioactive Peptides and Nonpeptides: Some Perspectives in Design 132
I. Introduction 132
II. Design of Nonpeptidic Peptidomimetics 139
III. Conclusions 154
ACKNOWLEDGMENTS 154
References 154
Chapter 4. Dynamic Systems Analysis as a Basis for Drug Design: Application to Antihypertensive Drug Action 158
I. Introduction 159
II. Dynamics of Drug Action 161
III. Antihypertensive Drugs: Dynamics of the Interactions with the Cardiovascular System 170
IV. Pharmacotherapy of Hypertensive Disease 194
V. Dynamic Systems Analysis as a Basis for Drug Design 197
References 199
Chapter 5. Polymeric Drug Delivery Systems 206
I. Introduction 206
II. Polymers as Physical Carriers of Drugs 209
III. Polymers as Chemical Carriers of Drugs 236
IV. Conclusions 259
References 260
Chapter 6. The Design of Biocompatible Polymers 264
I. Introduction 264
II. Biocompatibility 267
III. Passive Tissue Implants 269
IV. Blood Compatible Polymers 277
References 284
Chapter 7. The Design of Insect Repellents 290
I. Introduction and Background 290
II. Design Concepts 296
III. Future Trends in Repellent Development 313
References 315
Chapter 8. Multivariate Data Analysis in Structure–Activity Relationships 320
I. Multivariate Data Analysis and Statistics 321
II. Multivariate Models of Dependence 322
III. Multivariate Models of Interdependence 326
IV. Program DATASCOPE for Multivariate Data Analysis 332
V. Applications of Multivariate Data Analysis 339
VI. Conclusion 352
ACKNOWLEDGEMENTS 353
References 353
Chapter 9. The Masca Model of Pharmacochemistry: II. Rational Empiricisms in the Multivariate Analysis of Opioids 356
I. Introduction 357
II. Blood-Brain Barrier 358
III. Morphinomimetic Polypeptides, Opioid Receptor Activity, and Correlation with Analgesia 363
IV. Discrimination of Structure–Analgesic and Structure-Antidiarrheal Relationships 365
V. Albumin Binding 367
VI. Recognition of Analgesics That Are of Special Interest in Multivariate Data Analysis 368
VII. Concluding Remarks 407
References 410
Index 416
Contents of Other Volumes 440

Produkt-Details

• Erscheint lt. Verlag: 22.10.2013
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie
• ISBN-10: 1-4832-1611-X / 148321611X
• ISBN-13: 978-1-4832-1611-9 / 9781483216119